1-Carbaminoyloxy-2-Benzyloxy-3-(2-Methoxy-Phenoxy)-Propan置于palladium On Activated Charcoal 氢气体系中,化学反应生成 美索巴莫 参考文献:ber Acylwanderung Und Acylabspaltung An Den Beiden Isomeren Monocarbaminsureestern Des 3-Guajacylglycerinthers Und Ihren O-Acetylverbindungen 标题:ber Acylwanderung Und Acylabspaltung An Den Beiden Isomeren Monocarbaminsureestern Des 3-Guajacylglycerinthers Und Ihren O-Acetylverbindungen 摘要: DOI:10.1007/bf00900262
专利号:US-7309799-B2 优先权日:2004-06-01 标 题:Methods for the synthesis of milnacipran and congeners thereof 发明人:BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V 权利人:COLLEGIUM PHARMACEUTICAL INC 摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.
专利号:US-7300639-B2 优先权日:2002-12-03 标 题:Process for removing metals from liquids 发明人:LIU WANSHENG 权利人:BRISTOL MYERS SQUIBB CO 摘要:A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , HET, and X-Z are as described herein, which process comprising the step of removing one or more metals from a solution of the compound of formula I or an intermediate or precursor thereof. The processes for removing metal comprise the step of contacting the liquid with a solid extractant comprising a metal-binding functionality.
专利号:US-2005282898-A1 优先权日:2004-06-01 标 题 :Methods for the synthesis of milnacipran and congeners thereof
专利号:EP-4630405-A1 优先权日:2022-12-06 标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
专利号:WO-2024123815-A1 优先权日:2022-12-06 标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
专利号:US-9265748-B2 优先权日:2011-08-11 标题 :Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use 发明人:RAILLARD STEPHEN P; MANTHATI SURESH K; JOSHI SUDHIR 权利人:XENOPORT INC 摘要:Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
1: Dobek CE, Dipinto AA, Kuan AJ, Lam RW, Blumberger DM, Downar J, Daskalakis ZJ, Vila-Rodriguez F. Sinus Tachycardia Induced by Methocarbamol and Repetitive Transcranial Magnetic Stimulation (rTMS). Brain Stimul. 2016 Jan-Feb;9(1):156-8. doi: 10.1016/j.brs.2015.10.012. Epub 2015 Nov 24. doi: 10.1007/s15006-015-3307-x. Epub 2015 Jul 13. German. doi: 10.1016/j.saa.2015.01.017. Epub 2015 Jan 21. doi: 10.1002/jssc.201400614. Epub 2014 Oct 21. doi: 10.1016/j.saa.2014.02.142. Epub 2014 Mar 12. doi: 10.1055/s-0033-1358703. Epub 2013 Nov 20. doi: 10.1111/jvp.12068. Epub 2013 Jul 17. doi: 10.1007/s10895-013-1276-9. Epub 2013 Aug 3. doi: 10.5326/JAAHA-MS-5835. Epub 2013 Mar 27. doi: 10.1111/vec.12070. Epub 2013 Jul 15. doi: 10.1002/bio.2386. Epub 2012 Jun 20. doi: 10.3928/01477447-20130122-54. doi: 10.2478/v10007-012-0016-z. doi: 10.1016/j.talanta.2011.06.066. Epub 2011 Jul 2. doi: 10.1002/dta.216. Epub 2010 Dec 29. doi: 10.1007/s10895-010-0742-x. Epub 2010 Oct 9.
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