CAS: 591-35-5; 3,5-Dichlorophenol

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CAS号1338215-37-4 [2-(3,5-dichlor... | CAS号68716-51-8 3,5-二氯苯硼酸频哪醇酯 | CAS号33719-74-3 3,5-二氯苯甲醚 | CAS号124-41-4 甲醇钠 | CAS号108-70-3 均三氯苯 | CAS号3032-81-3 3,5-二氯碘苯 | CAS号99-30-9 2,6-二氯-4-硝基苯胺 | CAS号1046862-08-1 2-(2,4-dichloro... | CAS号33719-74-3 3,5-二氯苯甲醚 | CAS号19046-87-8 3,5-dichloro-2,... | CAS号1940-28-9 4-溴-3,5-二氯苯酚 | CAS号245116-17-0 3-氯-5-羟基苯甲酸苄酯 | CAS号26271-75-0 4-amino-3,5-dic... | CAS号24910-68-7 1,3-dichloro-5-... | CAS号110784-42-4 3,5-dichloro 2-... | CAS号110784-43-5 3,5-dichloro 2,... | CAS号87-86-5 五氯苯酚

苯酚置于氯体系中,45.0 °C,1.0 Mpa 条件下,反应 12.0H,反应生成 3,5-二氯苯酚
参考文献:一种3,5-二甲基苯甲醛的合成方法
标题:一种3,5-二甲基苯甲醛的合成方法
摘要:本发明公开了一种3,5二甲基苯甲醛的合成方法,属于有机化学合成技术领域.本发明以苯酚为原料,通过氮气的通气反应生成3,5二氯苯酚,之后再加入三氯化磷溶液,H2So4溶液,锌粉以及铁粉,反应反应生成3,5二甲氧基苯酚,随后在反应生成的3,5二甲氧基苯酚中加入nahco3以及hci溶液,搅拌反应后再在其中加入zno,Zro2,Cao和mgo,从而制得一种浅黄色3,5二甲基苯甲醛.本发明操作简单易行,最终产率为85%以上.

专利信息

专利号:US-7696389-B2
优先权日:2006-03-24
标 题 :Method for reducing microcontaminants during synthesis of pentachlorophenol
发明人：SAVAGE PHILLIP E; YU JIANLI
权利人:UNIV MICHIGAN
摘要:A method for reducing contaminants during synthesis of pentachlorophenol includes providing a phenol-based starting material and a catalyst, which form a reaction mixture. A chlorine flow is introduced so that it is in contact with the reaction mixture, and the starting material and chlorine are reacted via a temperature-programmed reaction. The chlorine flow is terminated at a predetermined temperature prior to an end of the temperature-programmed reaction and/or at a point where the yield of pentachlorophenol is less than about 95%.

专利号:WO-2024185775-A1
优先权日:2023-03-06
标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same
发明人：OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi
权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY
摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group.　The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.

专利号:WO-2025149479-A1
优先权日:2024-01-12
标题:Synthesis of modified nucleoside triphosphates
发明人：KUCHELMEISTER HANNES; PFAFFENEDER TONI; MEX MARTIN; VETH SIMON; MENKE JAN-MICHAEL
权利人:ROCHE DIAGNOSTICS GMBH
摘要:The invention relates to a new diastereoselective synthesis method for highly modified nucleoside triphosphates with two conjugable groups. The method works in liquid phase with conventional laboratory equipment as used in any chemical laboratory or production. For this, a new chiral P(V) phosphorylation reagent has been designed that allows highly efficient diastereoselective synthesis under mild conditions. Overall, a highly efficient, diastereoselective, high quality, cost-effective synthetic method of modified nucleoside triphosphates has been developed.

专利号:WO-2022220019-A1
优先权日:2021-04-16
标题 :Long-chain dna synthesis using non-natural base
发明人：MASAKI YOSHIAKI
权利人:TOKYO INST TECH
摘要:The purpose of the present invention is to provide a method for synthesizing a long-chain nucleic acid (particularly DNA) with high accuracy. The present invention provides a method for synthesizing a long-chain nucleic acid, the method comprising using: (i) a nucleoside-3'-O-phosphoramidite derivative having a non-natural nucleic acid base; or (ii) a nucleoside-3'-O-phosphoramidite derivative having a non-natural nucleic acid base and a nucleoside-3'-O-phosphoramidite derivative having a natural nucleic acid base in the chemical synthesis of a nucleic acid based on the phosphoramidite method.

专利号:WO-2025082632-A1
优先权日:2023-10-16
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU
权利人:BACHEM HOLDING AG
摘要:The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)# to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.

专利号:EP-4605403-A1
优先权日:2022-10-17
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.