CAS: 63422-71-9; (R)-2-(4-Ethyl-2,3-Dioxopiperazine-1-Carboxamido)-2-Phenylacetic Acid

专利信息

专利号:US-4794108-A
优先权日:1984-04-24
标题:1-carboxymethoxy acetidinones and their production
发明人：KISHIMOTO SHOJI; SENDAI MICHIYUKI; OCHIAI MICHIHIKO
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:A 2-azetidinone derivative having a group of the formula wherein R1 and R2 are the same or different and each represents a hydrogen atom, alkyl, aryl or arylalkyl which may have a substituent at the 1-position and an amino group, at the 3-position, which may be acylated or protected, its salt or ester, and methods of producing the same, (1) a method comprising subjecting a 2-azetidinone derivative having a group of the formula wherein the symbols are as defined above at the 1-position and an amino group at the 3-position, its salt or ester to an acylation or protective-group introduction reaction, and (2) a method comprising reacting a 2-azetidinone derivative having a hydroxy group at the 1-position and an amino group, at the 3-position, which may be acylated or protected, or its salt with a compound of the formula wherein W is a halogen atom; other symbols are as defined above, its salt or ester. The above objective compounds are utilizable as excellent antimicrobial agents or as valuable intermediates for the synthesis of the same.

专利号:EP-0135194-A1
优先权日:1983-09-16
标题:Azetidinones and their production
发明人：KISHIMOTO SHOJI; SENDAI MICHIYUKI; OCHIAI MICHIHIKO
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:A 2-azetidinone derivative having a group of the formulan wherein R' and R 2 are the same or different and each represents a hydrogen atom, alkyl, aryl or arylalkyl which may have a substituent at the 1-position and an amino group, at the 3-position, which may be acylated or protected, its salts or ester, and methods of producing the same,n (1) a method comprising subjecting a 2-azetidinone derivative having a group of the formulan wherein the symbols are as defined above at the 1-position and an amino group at the 3-position, its salt or ester to an acylation or protective-group introduction reaction, and (2) a method comprising reacting a 2-azetidinone derivative having a hydroxy group at the 1-position and an amino group at the 3-position, which may be acylated or protected, or its salt with a compound of the formulan wherein W is a halogen atom; other symbols are as defined above, its salt or ester. The above objective compounds are utilizable as excellent antimicrobial agents or as valuable intermediates for the synthesis of the same.