CAS: 6602-54-6; 2-Chloronicotinonitrile

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3-氰基吡啶置于双氧水,Bis(2,4-Pentanedionato)Dioxomolybdenum(Vi),三氯氧磷体系中,用 水 作为反应溶剂,化学反应 5.5H,反应生成 2-氯-3-氰基吡啶
参考文献:一种生产2-氯烟酸的方法
标题:一种生产2-氯烟酸的方法
摘要:本发明公开了一种生产2‑氯烟酸的方法,其步骤包括:S1:在反应器内加入乙酰丙酮酸钼,水,3‑氰基吡啶,搅拌,室温下滴加过氧化氢,滴完后保温反应5H,结束后升温至70‑80°C,滴入2%碳酸铵溶液,至ph=7,然后抽滤,滤饼80oc烘干;s2:加3‑氰基吡啶氮氧化物,抽真空后,加过量三氯氧磷,搅拌均匀30分钟,温度控制在20oc下从高位滴加三乙胺,滴完后升温至60oc‑70°C,保温3‑4H,结束后减压蒸馏回收三氯氧磷,将物料转移至氯化水解反应器内,然后在10oc下滴加氢氧化钠调ph=2让物料析出,抽滤干燥得2‑氯‑3氰基吡啶;s3:加水和2‑氯‑3‑氰基吡啶转,在常温下滴加氢氧化钠溶液调ph=4,然后水洗抽滤,干燥得2‑氯烟酸.本发明工艺无苛刻条件,对环境友好且适合工业化生产.

专利信息

专利号:US-6852855-B2
优先权日:1999-04-19
标 题 :Synthesis of piperazine ring
发明人：DOLITZKY BEN-ZION
权利人:TEVA PHARMA
摘要:A novel process for preparing a compound of the formula I: n n nwhereinn nR 1 denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy; R 2 denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy, arylalkoxy, tosyl, formyl, acetyl or amine; and R 3 denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy is disclosed. These compounds are useful in the synthesis of the antidepressant mirtazapine and other tetracyclic compounds.

专利号:WO-2016118586-A1
优先权日:2015-01-20
标 题 :Lowcost, high yield synthesis of nevirapine
发明人：AHMAD SAEED; GUPTON FRANK; VERGHESES JENSON; MCQUADE TYLER
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:Improved methods of producing the HIV drug substance, nevirapine are provided. The methods employ a cost effective and high yield synthetic methods for preparing the nevirapine building block 2-chloro-3-amino-4-picoline (CAPIC) and 2-cyclopropyl amino nicotinate (Me-CAN), and improvements in other steps of nevirapine synthesis.

专利号:US-6603003-B2
优先权日:2000-11-07
标 题 :Method for the preparation of piperazine and its derivatives
发明人：SEBASTIAN SONNY; PATEL HETAL VIRENDRA; THENNATI RAJAMANNAR
权利人:SUN PHARMACEUTICAL IND LTD
摘要:A novel method for the synthesis of piperazine and its derivatives of formula 1,wherein R is selected from hydrogen, or a lower alkyl group having 1 to 6 carbon atoms or a phenylalkyl group the alkyl of which has 1 to 4 carbon atoms;R1 is selected from hydrogen, a methyl group, a phenyl group optionally substituted with an alkyl group having 1 to 6 carbon atoms, or a phenylalkyl group the alkyl of which has 1 to 4 carbon atoms; andR2 is selected from hydrogen, or a methyl group, or a fluoromethyl group;comprising the steps:a. reacting an ester of formula 11 with substituted or unsubstituted ethylenediamine of formula 7 to give 3,4-dehydropiperazine-2-one and its derivatives of formula 12, wherein R, R1, R2 are as defined above and R6 is a C1 to C4 linear or branched alkyl group; andb. reacting the 3,4-dehydro-piperazine-2-one and its derivatives of formula 12 with a reducing agent to yield the piperazine and its derivatives of formula 1.

专利号:US-11718596-B2
优先权日:2014-03-19
标题 :Amyloid targeting agents and methods of using the same
发明人：YANG JERRY; THEODORAKIS EMMANUEL A; SARRAF STELLA
权利人:UNIV CALIFORNIA; AMYDIS INC
摘要:Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.

专利号:US-5204478-A
优先权日:1992-08-20
标题 :Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride
发明人：JENNINGS REX A
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid.

专利号:US-2002035256-A1
优先权日:1999-04-19
标题:Novel synthesis of piperazine ring