CAS: 82964-91-8; 4-(Methylsulfonyl)Benzene-1-Sulfonyl Chloride

上下游产品

4-(methylsulfanyl)benzenesulfonyl chloride 4-methanesulfonylphenylamine N-(4-methanesulfonylphenyl)acetamide sodium 4-acetamidobenzenesulfinate 4-(methylsulfonyl)-benzenesulfinic acid 4-methanesulfonyl-benzenesulfonic acid 6-(4-Methanesulfonyl-benzenesulfonylamino)-2-(3-pyridin-3-yl-propyl)-hexanoic acid ethyl ester 4-Methanesulfonyl-benzenesulfonic acid 2,4,6-tribromo-phenyl ester

4-甲磺酰基苯胺置于盐酸,Sodium Nitrite,二氧化硫,Copper Dichloride体系中,用 水,溶剂黄146 作为反应溶剂,化学反应生成 4-甲基磺酰苯磺酰氯
参考文献:血小板活化因子(paf)中的构效关系.11从paf拮抗作用到磷脂酶a(2)抑制:1-芳基磺酰胺基-2-烷基哌嗪的合成与结构活性关系.
标题:血小板活化因子(paf)中的构效关系.11从paf拮抗作用到磷脂酶a(2)抑制:1-芳基磺酰胺基-2-烷基哌嗪的合成与结构活性关系.
摘要:1-苄基-2-烷基哌嗪是i和ii组分泌的pla(2)s的强抑制剂.通过用磺酰胺取代酰胺官能团并通过在苯磺酰基部分的对位引入电子给体取代基,可以提高其活性.哌嗪环的一个碳原子上的位置或该碳原子的绝对构型都不会影响对pla(2)的一个或另一个基团的亲和力,但亲脂性对于这些系列仍然是必不可少的参数.此外,结构活性关系允许这些哌嗪衍生物与pla(2)s催化位点相互作用的新假设.
DOI:10.1016/s0223-5234(01)01274-0

专利信息

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-2004102389-A1
优先权日:1995-10-26
标题 :Nucleic acid-mediated treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
发明人：PAVCO PAMELA; MCSWIGGEN JAMES; STINCHCOMB DAN; ESCOBEDO JAIME; KIM JULIAN; LINDNER DANIEL
权利人:RIBOZYME PHARM INC
摘要:The present invention relates to nucleic acid molecules such as ribozymes, DNAzymes, short interfering RNA (siRNA), short interfering nuleic acid (siNA), and antisense which modulate the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor, such as flt-1 (VEGFR1) and/or KDR (VEGFR2). Nucleic acid molecules and methods for the inhibition of angiogenesis and treatment of cancer and other conditions associated with VEGF-R are provided, optionally in conjunction with other therapeutic agents such as interferons.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-7977371-B2
优先权日:2007-02-26
标题 :Pyrrole derivative having ureido group and aminocarbonyl group as substituents
发明人：KAWASHIMA KENJI; ENOMOTO HIROSHI; ISHIZAKA NORIKO; YAMAMOTO MINORU; KUDOU KAZUHIRO; MURAI MASAAKI; INABA TAKAAKI; OKAMOTO KAZUYOSHI
权利人:SANTEN PHARMACEUTICAL CO LTD
摘要:Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to find a medicinal agent which has a prophylactic and/or therapeutic effect on a retinal disease or the like through oral administration. A compound represented by the general formula (1) or a salt thereof has an inhibitory activity against the production of interleukin-6 and/or an inhibitory effect on choroidal neovascularization, and is therefore useful as a prophylactic and/or therapeutic agent for a disease associated with interleukin-6, an ocular inflammatory disease and/or a retinal disease. In the formula, the ring A represents a benzene ring or the like; R 1 represents a halogen atom, a hydrogen atom, a lower alkyl group or the like; R 2 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group, a lower alkynyl group which may have a substituent, a lower cycloalkyl group, an aryl group, a hydroxy group, a lower alkoxy group which may have a substituent or the like; and n represents 0, 1, 2, 3 or the like.

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries