5-氨基水杨酸置于硫酸体系中,化学反应生成5-碘水杨酸 参考文献:Brenans; Prost,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1923,Vol. 176,P. 1628 标题:Brenans; Prost,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1923,Vol. 176,P. 1628
专利号:US-10005720-B2 优先权日:2013-04-05 标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same 发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L 权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL 摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
专利号:US-8193360-B2 优先权日:2003-07-31 标 题:Radiolabelled fluorobenzamide analogues, their synthesis and use in diagnostic imaging 发明人:MACH ROBERT H; TU ZHUDE 权利人:MACH ROBERT H; TU ZHUDE; UNIV WASHINGTON 摘要:Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18 F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labelled with 123 I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-2018370905-A1 优先权日:2013-04-05 标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same
专利号:PL-449176-A1 优先权日:2024-07-09 标 题:Method of simultaneous biofortification of vegetables with zinc and iodine, method of synthesis of zinc 5-iodosalicylate and application of zinc 5-iodosalicylate in vegetable crops
专利号:PL-449177-A1 优先权日:2024-07-09 标 题 :Method of simultaneous biofortification of vegetables with zinc and iodine, method of synthesis of zinc 3,5-diiodosalicylate and use of zinc 3,5-diiodosalicylate in vegetable crops
[参考文献]: Luís Gales, Et Al. Iodination Of Salicylic Acid Improves Its Binding To Transthyretin. Biochim Biophys Acta. 2008 Mar;1784(3):512-7.
合成参考文献
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