CAS: 131328-27-3; (S)-1-(Tetrahydrofuran-2-yl)Ethan-1-One

相似化合物

25252-64-6 666203-86-7 907961-91-5

上下游产品

(S)-tetrahydrofuran-2-carbonitrile methylmagnesium chloride

在 溶剂黄146体系中,用 水 用作溶剂,以77.6%的收率获得1-[(2S)-四氢-2-呋喃基]乙酮
参考文献:一种高光学纯度1-[四氢-2-呋喃基]乙酮的工 业化制备方法
标题:一种高光学纯度1-[四氢-2-呋喃基]乙酮的工 业化制备方法
摘要:本发明公开了一种高光学纯度1‑[四氢‑2‑呋喃基]乙酮的工业化制备方法,属于化学合成领域,包括如下步骤:以四氢呋喃甲酸为原料,与羰基二咪唑反应,然后加入丙二酸亚异丙酯进行缩合,然后在酸性条件进行水解,最后萃取,浓缩得产品乙酰基四氢呋喃;本发明制备高光学纯度1‑[四氢‑2‑呋喃基]乙酮的工艺,原料成本低,不需要使用格氏试剂,产品性状稳定,纯度可达98%以上,光学纯度可达99%以上,收率可达70%以上;本工艺经过了实际工业化生产验证,质量稳定,反应条件温和,操作安全可靠,工艺重现性好,制备成本低,是一种可靠的高光学纯度1‑[四氢‑2‑呋喃基]乙酮的工业化制备方法.

专利信息

专利号:US-11840544-B2
优先权日:2018-07-02
标 题 :Intermediates in the synthesis of C3-substituted cephalosporins
发明人：MADELA KAROLINA
权利人:NORBROOK LAB LTD
摘要:Disclosed herein are novel and inventive methods for preparing intermediates in the synthesis of C3-substituted cephalosporins. One preferred C3-substituted cephalosporin of clinical interest is Cefovecin. Accordingly, the present invention provides for methods of preparing reactive halogen intermediates for use in the synthesis of C3-substituted cephalosporins, such as Cefovecin. In the case of Cefovecin the reactive intermediates are of the formula:

专利号:WO-2020008183-A1
优先权日:2018-07-02
标 题:Intermediates in the synthesis of c3-substituted cephalosporins

专利号:EP-3818059-B1
优先权日:2018-07-02
标题 :Intermediates in the synthesis of c3-substituted cephalosporins

专利号:US-2021261571-A1
优先权日:2018-07-02
标 题 :Intermediates in the synthesis of c3-substituted cephalosporins

专利号:GB-2575261-A
优先权日:2018-07-02
标题:Intermediates in the synthesis of C3-substituted cephalosporins

专利号:CA-3104110-A1
优先权日:2018-07-02
标 题:Intermediates in the synthesis of c3-substituted cephalosporins