欧盟法规
REACH注册ECHA物质C&L通报REACH预注册上下游产品
triphenylphosphine 4CPh)2]trans-[Pd(triphenylphosphine)2(N4CPh)2] benzoyl chloride tetrachloropalladium anion(0)bis(1,2-bis(diphenylphosphinoethynyl)benzene)palladium(0) (E)-3,5-diphenylpent-2-en-4-ynoic acid methyl ester N-(tert-butoxycarbonyl)4-(2-thiazolyl)-L-phenylalanine methyl ester 2-amino-3,5-diphenyl-pyridinePotassium Tetrachloropalladate(II)置于三苯基膦体系中,用 水,丙酮 用作溶剂,化学反应生成双三苯基磷二氯化钯
参考文献:Polovnyak,V. K.; Busygina,T. E.; Akhmetov,N. S. A.,Russian Journal Of Inorganic Chemistry,1985,Vol. 30,P. 222-224
标题:Polovnyak,V. K.; Busygina,T. E.; Akhmetov,N. S. A.,Russian Journal Of Inorganic Chemistry,1985,Vol. 30,P. 222-224
专利信息
专利号:US-5849936-A
优先权日:1995-03-15
标题:Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins
发明人:HOYE THOMAS R; TAN LUSHI
权利人:UNIVERISTY OF MINNESOTA
摘要:A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.
专利号:US-8273790-B2
优先权日:2005-01-14
标 题:Exo-selective synthesis of himbacine analogs
发明人:THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D
权利人:THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D; SCHERING CORP
摘要:This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人:BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
专利号:US-12162849-B2
优先权日:2018-12-21
标题 :Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or of the methyl-d3 deuterated form thereof
发明人:HOVEYDA HAMID; DUTHEUIL GUILLAUME
权利人:OGEDA SA
摘要:The present invention relates to a method of synthesis of compound (I), wherein R1 represents methyl or methyl-d3, thus corresponding to 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or to the methyl-d3 deuterated form thereof. These compounds are useful as key intermediates in the synthesis of pharmaceutical compounds, especially fezolinetant and deuterated fezolinetant.
专利号:US-8329769-B2
优先权日:2009-12-10
标题:Facile synthesis of microporous triple-bond based polymer networks using acetylene gas as a building unit
发明人:KANG JEUNG-KU; CHOI JUNG-HOON; CHOI KYUNG-MIN; JEON HYUNG-JOON; CHOI YOON-JEONG; LEE YEOB
权利人:KANG JEUNG-KU; CHOI JUNG-HOON; CHOI KYUNG-MIN; JEON HYUNG-JOON; CHOI YOON-JEONG; LEE YEOB; KOREA ADVANCED INST SCI & TECH
摘要:Disclosed is a method for synthesis of micro-porous triple-bond based polymer networks using acetylene gas. According to the disclosed methods for synthesis of micro-porous triple-bond based polymer networks, acetylene gas interconnects building units having iodine and/or bromine functional groups by coupling reactions to provide micro-porous triple-bond based polymer networks.
专利号:US-6271379-B1
优先权日:2000-03-08
标题:Intermediates useful for the synthesis of huperzine A
发明人:TUECKMANTEL WERNER; KOZIKOWSKI ALAN P
权利人:UNIV GEORGETOWN
摘要:Intermediates useful for the synthesis of huperzine A represented by the structures below, n and methods for their synthesis, wherein: n R 1 is lower alkyl, benzyl, or substituted benzyl; n X is a suitable leaving group; n Y is an electron withdrawing group that can subsequently be converted into an amino group; n one broken line is present as a carbon—carbon bond and the other broken line is absent, where the broken line forms an unconjugated carbon—carbon double bond, which double bond may be endocyclic whereby n is 3 or the double bond may be exocyclic whereby n is 2.