CAS: 23735-43-5; (S)-(2,2-Dimethyl-1,3-Dioxolan-4-yl)Methyl 4-Methylbenzenesulfonate

上下游产品

CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号14347-78-5 (R)-(-)-甘油醇缩丙酮 | CAS号15042-01-0 5,6-O-异丙叉基-L-抗坏血酸 | CAS号22323-82-6 (S)-(+)-甘油醇缩丙酮 | CAS号22323-80-4 L-甘油醛缩丙酮 | CAS号50765-70-3 (S)-1-对甲苯磺酰氧基-2... | CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号4306-35-8 1-(2,2-dimethyl... | CAS号67-64-1 丙酮 | CAS号143393-27-5 阿扎兰司他 | CAS号50765-70-3 (S)-1-对甲苯磺酰氧基-2... | CAS号23735-44-6 2,2-dimethyl-4(... | CAS号144256-11-1 (S)-(2,2-二甲基-1,... | CAS号133242-30-5 兰地洛尔 | CAS号22195-47-7 2,2-二甲基-1,3-二氧戊... | CAS号74923-97-0 (R)-2,2-二甲基-1,3...

在 吡啶,Lead(Iv) Acetate,Sodium Tetrahydroborate体系中,用 乙醇,乙酸乙酯 用作溶剂,化学反应 6.0H,反应生成对甲苯磺酸(S)-(-)-2,2-二甲基-1,3-二氧戊环基-4-基甲基酯
参考文献:(R)-和(S)-5-羟甲基-2-恶唑烷酮及其衍生物的有效途径
标题:(R)-和(S)-5-羟甲基-2-恶唑烷酮及其衍生物的有效途径
摘要:2-恶唑烷酮由于其各种药理作用而成为一类非常有趣的化合物.从d-甘露醇,L-抗坏血酸和(R)-或(S)-苹果酸开始,已开发出两个对映体纯的(R)-和(S)-5-羟甲基-2-恶唑烷酮的新合成方法.(R)-和(S)-5-羟甲基-2-恶唑烷酮已用于合成一些新的手性2-恶唑烷酮衍生物.
Doi:10.1016/0957-4166(95)00144-E

专利信息

专利号:US-4806655-A
优先权日:1986-07-03
标题:Process for the stereospecific synthesis of indole derivatives
发明人：WAGNON JEAN; PLOUZANE CLAUDE; TONNERRE BERNARD; NISATO DINO
权利人:SANOFI SA
摘要:The present invention relates to a process for the stereo-specific synthesis of indole derivatives of formula: ##STR1## which consists in using 3-tosyloxy-1,2-O-isopropylidenepropane-1,2-diol (II) in an optically pure form in order to introduce the asymetric carbon C* of compound (I). Compound (II) is condensed with a suitable primary amine in order to prepare an oxazolidinone and condensation with a suitable phenol, and the oxazolidinone ring is then opened to form an indole compound (I).

专利号:US-2015031898-A1
优先权日:2012-03-09
标题 :Process for preparation of prostaglandin f2 alpha analogues
发明人：DAMS IWONA; KUTNER ANDRZEJ; CHODYNSKI MICHAL; KRUPA MALGORZATA; PIETRASZEK ANITA; ZEZULA MARTA; CMOCH PIOTR; KOSINSKA MONIKA
权利人:INST FARMACEUTYCZNY
摘要:A convergent synthesis of the prostaglandin F 2α analogues, travoprost and bimatoprost, was developed employing Julia-Lythgoe olefination of the structurally advanced phenylsulfone with an enantiomerically pure aldehyde ω-chain synthon. The novel convergent strategy allows the synthesis of a whole series of prostaglandin analogues of high purity from a common and structurally advanced prostaglandin intermediate.

专利号:US-8445510-B2
优先权日:2010-05-14
标题 :Fused bicyclic kinase inhibitors
发明人：MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING
权利人:MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.

专利号:US-7501430-B2
优先权日:2006-04-17
标题:RAF inhibitors and their uses
发明人：LAPIERRE JEAN-MARC; NAMDEV NIVEDITA D; ASHWELL MARK A; FRANCE DENNIS S; WU HUI; HUTCHINS PATRICK M; TANDON MANISH; LIU YANBIN; LINK JEFF S; ALI SYED M; BRASSARD CHRIS J; NICEWONGER ROBB B; FILIKOV ANTON; CARAZZA REBECCA J
权利人:ARQULE INC
摘要:The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAF V600E . The compounds are useful for the treatment of cell proliferative disorders such as cancer.