CAS: 28371-16-6; (R)-1,8-Dihydroxy-3-(Hydroxymethyl)-10-((2S,3R,4R,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Anthracen-9(10H)-One
该化合物是属于类炭疽的化学化合物,以其多种生物活动著称,主要来自阿洛植物,特别是Aloe vera, 并且经常与其消毒特性相关.Aloin B的特征是黄色到棕色的颜色,通常在阿洛叶的乳胶中找到.该化合物显示出各种药理效应,包括抗炎和抗微生物特性,因此对传统医学和现代药理学都感兴趣.Aloin B还研究其潜在的抗氧化效应,这可能有助于治疗用途.然而,必须指出,尽管其具有有益特性,过度消费可能导致不利影响,特别是胃肠脱肠.与许多自然化合物一样,Aloin B的安全和功效取决于剂量和个人健康状况.
- 英文名称(R)-1,8-Dihydroxy-3-(Hydroxymethyl)-10-((2S,3R,4R,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Anthracen-9(10H)-One
- 中文名称异芦荟苷
- IUPAC名称(R)-1,8-dihydroxy-3-(hydroxymethyl)-10-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)anthracen-9(10H)-one
- 其它别名9(10H)-Anthracenone,10-b-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-,(R)-; Anthrone, 10-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-,stereoisomer (8CI); Isobarbaloin (7CI); Aloin; Aloin B
- CAS编号28371-16-6
- MFCD编号:MFCD00869345
- EINECS号:110-054-8
- FDA UNII编号:69VIB0J2WK
- 分子式:C21H22O9
- 分子量:418.4
- 产品CID: 1264010
- 同类组份化合物CAS1415-73-2 (A)28371-16-6 (B)
- 产品分类原料药 → 消化系统用药 → 泻药止泻药
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(经口)
- 警示词Warning(警告)
- 危险描述H302 |吞咽有害.
- 防范说明P501-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
- 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- WGK Germany3
欧盟法规
C&L通报上下游产品
芦荟素,葡糖基蒽酮,芦荟大黄素甙 (10S)-1,8-Dihydroxy-3-(Hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]-10H-Anthracen-9-One 1415-73-2合成工艺路线路线简述
芦荟素,葡糖基蒽酮,芦荟大黄素甙 以35%的收率获得
参考文献:Manitto,Paolo;Monti,Diego;Speranza,Giovanna,J. Chem. Soc. Perkin Trans. Pt 1,(1990) N,C. 1297
标题:Manitto,Paolo;Monti,Diego;Speranza,Giovanna,J. Chem. Soc. Perkin Trans. Pt 1,(1990) N,C. 1297
海关参考信息
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2905310000-1,2-乙二醇
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- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7790765-B2
优先权日:2007-04-30
标题:Hydroxy sulfonate of quinone compounds and their uses
发明人：BARTIS JUDIT; VOLCKOVA ERIKA; TANDON MANISH; LOWE DEIRDRE; REDMON MARTIN P
权利人:ARQULE INC
摘要:The present invention provides sodium 6-hydroxy-2,2-dimethyl-5-oxo-3,4,5,6-tetrahydro-2H-benzo(h)chromene-6-sulfonate, and its synthesis and uses in the treatment of cancer.
专利号:US-4215062-A
优先权日:1978-05-22
标 题 :Anthracycline synthesis
发明人：MITSCHER LESTER A
权利人:KANSAS UNIV ENDOWMENT ASS THE
摘要:A process for synthesizing doxorubicin and related compounds from aloe-emodin is disclosed. Intermediates useful in the preparation of doxorubicin and related compounds are also disclosed.
专利号:WO-2008090078-A1
优先权日:2007-01-18
标题 :Method for the synthesis of rhein and derivatives thereof
专利号:FR-2911602-A1
优先权日:2007-01-18
标题 :PROCESS FOR THE SYNTHESIS OF THE RHEIN AND ITS DERIVATIVES
专利号:FR-2907118-A1
优先权日:2006-10-11
标题:NEW SYNTHESIS OF RHEINE AND PRECURSOR COMPOUNDS
专利号:WO-2022236844-A1
优先权日:2021-05-13
标 题 :Phenylhydrazone derivative of aglycone aloesone having antioxidant activity and synthesis method therefor
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📌 第三方产品分析报告
主要参考文献
1: Ma Y, Tang T, Sheng L, Wang Z, Tao H, Zhang Q, Zhang Y, Qi Z. Aloin suppresses lipopolysaccharide‑induced inflammation by inhibiting JAK1‑STAT1/3 activation and ROS production in RAW264.7 cells. Int J Mol Med. 2018 Oct;42(4):1925-1934. doi: 10.3892/ijmm.2018.3796. Epub 2018 Jul 31.
2: Lewis DSM, Ho J, Wills S, Kawall A, Sharma A, Chavada K, Ebert MCCJC, Evoli S, Singh A, Rayalam S, Mody V, Taval S. Aloin isoforms (A and B) selectively inhibits proteolytic and deubiquitinating activity of papain like protease (PLpro) of SARS-CoV-2 in vitro. Sci Rep. 2022 Feb 9;12(1):2145. doi: 10.1038/s41598-022-06104-y.
3: Gao J, Yang S, Xie G, Pan J, Zhu F. Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer. Drug Des Devel Ther. 2022 Jun 20;16:1947-1961. doi: 10.2147/DDDT.S360790.
合成参考文献
参考文献:10.1300/j044v04n03_04
摘要:Oketch-Rabah HAT. Leaf Compounds in Potential Plantation Species ofAloein Kenya. Journal of Herbs, Spices & Medicinal Plants. 1997 Apr 24;4(3):25–33. doi: 10.1300/j044v04n03_04.
参考文献:10.1016/s0031-9422(96)00799-6
摘要:Holzapfel CW, Wessels PL, Van Wyk B, Marais W, Portwig M. Chromone and aloin derivatives from Aloe broomii, A. Africana and A. speciosa. Phytochemistry. 1997 May;45(1):97–102. doi: 10.1016/s0031-9422(96)00799-6.
参考文献:10.1002/pca.2800050510
摘要:Rauwald HW, Sigler A. Simultaneous determination of 18 polyketides typical of Aloe by high performance liquid chromatography and photodiode array detection. Phytochemical Analysis. 1994 Sep;5(5):266–70. doi: 10.1002/pca.2800050510.
参考文献:10.1016/0305-1978(94)90102-3
摘要:Sigler A, Rauwald HW. First proof of anthrone aglycones and diastereomeric anthrone-C-glycosyls in flowers and bracts of Aloe species. Biochemical Systematics and Ecology. 1994 Apr;22(3):287–90. doi: 10.1016/0305-1978(94)90102-3.
参考文献:10.1016/0031-9422(96)00306-8
摘要:Okamura N, Hine N, Harada S, Fujioka T, Mihashi K, Yagi A. Three chromone components from Aloe vera leaves. Phytochemistry. 1996 Sep;43(2):495–8. doi: 10.1016/0031-9422(96)00306-8.
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