CAS: 32161-30-1; (S)-2-Amino-3-(3,4-Dimethoxyphenyl)Propionic Acid

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3-甲氧基-O-甲基-L-酪氨酸甲酯置于protease Type Viii,碳酸氢钠体系中,化学反应 5.0H,反应生成3,4-二甲氧基-L-苯丙氨酸
参考文献:New Synthetic Amino Acids For The Design And Synthesis Of Peptide-Based Metal Ion Sensors
标题:New Synthetic Amino Acids For The Design And Synthesis Of Peptide-Based Metal Ion Sensors
摘要:The Syntheses Of Two New Nonstandard Amino Acids,Flu (6) And Ybp (20),And A New Synthesis Of Dmd (12) Are Reported. These Residues Exhibit Fluorescence,Metal-Coordination,And Fluorescence-Quenching Properties,Respectively. These Building Blocks Have Been Incorporated Into Peptides Via Solid Phase Peptide Synthesis To Afford The Prototype Fur A Photoinduced Electron Transfer-Based Metal Ion Chemosensor. The Fluorescence Of The Peptides Is Modulated Upon Metal Binding. This Results From A Metal. Ion-Induced Conformational Change That Brings The Side Chains Of The Flu And Dmd Amino Acids Into Proximity,Thereby Favoring Photoinduced Electron Transfer (Pet) Fluorescence Quenching.
Doi:10.1021/jo961466W

专利信息

专利号:US-5041637-A
优先权日:1988-07-12
标题:Process for the synthesis of optically active aminoacids
发明人：CANNATA VINCENZO; TAMERLANI GIANCARLO; CALZOLARI CLAUDIO
权利人:PRESIDENZA DEL CONSIGLIO DEL M
摘要:New process for the synthesis of optically active aminoacids of formula ##STR1## by treating compounds of formula ##STR2## which an optically active alcohol of formula n n R.sub.4 --OH (III) n n n d or 1 n n To obtain a pair of diastereoiosmer esters of formula ##STR3## which is resolved in basic medium into the single diastereoisomer esters of formula ##STR4## from which the desired optically active aminoacid of formula (I) is obtained by treatment in acid medium.

专利号:US-2024218014-A1
优先权日:2022-11-21
标 题:Synthesis of a cyclic peptide
发明人：BAUR PIUS BRUNO; CLEATOR EDWARD; DENIAU GILDAS; EISELE FRANK; FLÖGEL OLIVER; HUSTE ANJA; KEHL MARCEL ROMAN; LÖWENECK MARKUS; SILVA ROLANDO RAVELO; VORBERG RAFFAEL
权利人:JANSSEN PHARMACEUTICA NV
摘要:Processes for performing peptide synthesis, particularly for cyclic peptide synthesis are generally described. Reaction intermediates of the peptide synthesis are also described.

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.