CAS: 327-57-1; (S)-2-Aminohexanoic Acid

相似化合物

616-06-8 6404-28-0 55674-63-0

上下游产品

For-Nle-OH 2-amino-hexanoic acid N-acetylnorleucine N-Acetyl-L-2-aminohexanoic acid L-norleucine methyl ester (S)-2-hydroxyhexanoic acid N-benzenesulfonyl-L-norleucineN-benzenesulfonyl-L-norleucine N-benzyloxycarbonyl-L-norleucine

己酸置于p450Cla,D-Isocaproate Dehydrogenase From Lactobacillus Confuses,L-Isocaproate Dehydrogenase From Lactobacillus Confuses,L-Phenylalanine Dehydrogenase From Rhodococcus Sp.,β-烟酰胺腺嘌呤二核苷酸,双氧水,碳酸氢铵,氯化铵体系中,用 Aq. Phosphate Buffer,乙醇 作为反应溶剂,化学反应 48.0H,反应生成 L-正亮氨酸
参考文献:通过羧酸的形式对映选择性生物催化胺化制备规范和非规范α-氨基酸的不对称合成
标题:通过羧酸的形式对映选择性生物催化胺化制备规范和非规范α-氨基酸的不对称合成
摘要:从可再生原料和使用温和的反应条件化学和生物催化合成非规范α-氨基酸(ncaas)尚未得到有效解决.在这里,我们展示了一种三步,可扩展且模块化的单锅生物梯级的开发,该级联可将可再生脂肪酸(fas)线性转化为对映纯l-α-氨基酸.在模块1中,P450过氧合酶p450 Cla催化fa的选择性α-羟基化.通过使用自动化的H2O 2补充系统,可以将多种fa(c6:0至c16:0)的fa有效转化(46%至> 99%; Ttn> 3300),转化为有价值的α-羟基酸(α-Has; > 90%α-选择性)以制备规模显示(最大2.3 G L-1隔离产品).在模块2中,氧化还原-中性氢借入级联反应(酒精脱氢酶/氨基酸脱氢酶)使α-Has进一步转化为l-α-Aas(20%至99%).对映体纯的l-α-Aas(ee> 99%),包括药物合成的l-高苯丙氨酸,产品滴定度最高可达2.5 G L-1.该生
DOI:10.1002/adsc.201801377

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:WO-9312076-A1
优先权日:1991-12-13
标题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS ROY
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-5283293-A
优先权日:1990-12-14
标 题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS R
权利人:CORVAS INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-7723082-B2
优先权日:2002-06-21
标题 :Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives
发明人：GONDRY MURIEL; GENET ROGER; LAUTRU SYLVIE; PERNODET JEAN-LUC
权利人:COMMISSARIAT ENERGIE ATOMIQUE; CENTRE NAT RECH SCIENT
摘要:The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides and diketopiperazine derivatives 3- and 6-substituted by α,β-unsaturated amino acid side chains.

专利号:US-5367072-A
优先权日:1990-12-14
标 题 :Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS R
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.