CAS: 376592-93-7; 3'-Amino-2'-Hydroxy-[1,1'-Biphenyl]-3-Carboxylic Acid

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CAS号376592-58-4 5'-氯-3'-硝基-2'-羟... | CAS号376591-95-6 2-羟基-3'-硝基-联苯-3-甲酸 | CAS号695-96-5 2-溴-4-氯苯酚 | CAS号25487-66-5 3-羧基苯硼酸 | CAS号376592-57-3 5-氯-2-羟基-[1,1-联... | CAS号89-64-5 4-氯-2-硝基苯酚 | CAS号15969-10-5 2-溴-4-氯-6-硝基苯酚

4-氯-2-硝基苯酚置于palladium 10% On Activated Carbon,氢气,溴,Palladium Diacetate,Sodium Carbonate,溶剂黄146,三乙胺体系中,用 甲醇,水 用作溶剂,5.0~50.0 °C,1.0 Mpa 条件下,反应 28.0H,反应生成3'-氨基-2'-羟基-[1,1'-联苯]-3-甲酸
参考文献: Processes For The Preparation Of An Intermediate In The Synthesis Of Eltrombopag[fr] Procédés De Préparation D'Un Intermédiaire Dans La Synthèse De L'Eltrombopag
标题: Processes For The Preparation Of An Intermediate In The Synthesis Of Eltrombopag[fr] Procédés De Préparation D'Un Intermédiaire Dans La Synthèse De L'Eltrombopag
摘要:3'-氨基-2'-羟基联苯-3-羧酸(bpca)及相关化合物已经利用化合物制备,其中r1为-H,-Cl或-F;R2为-Br或-I;R3为-H或-N02.例如,Bpca在埃替莫帕格的制备中是有用的.

专利信息

专利号:US-12435042-B2
优先权日:2019-07-04
标题:Process for the preparation of key intermediates for the synthesis of Eltrombopag or salt thereof
发明人：STABILE PAOLO; SEMERARO FLORIANA
权利人:F I S —FABBRICA ITALIANA SINTETICI S P A
摘要:Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of Eltrombopag, passing through/using intermediate 5′-Chloro-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid alkaline metal salt of formula: wherein A is an alkaline metal.

专利号:WO-2013049605-A1
优先权日:2011-09-28
标题 :Processes for the preparation of an intermediate in the synthesis of eltrombopag
发明人：AVDAGIC AMIR; BARAN PHIL S
权利人:ASSIA CHEM IND LTD; TEVA PHARMACEUTICAL USA INC
摘要:3'-Amino-2'-hydroxybiphenyl-3-carboxylic acid (BPCA) and related compounds have been prepared using compounds such as: wherein R 1 is -H, -Cl or -F; R 2 is -Br or -I; and R 3 is -H or -N0 2 . BPCA is useful, for example, in the preparation of Eltrombopag.

专利号:US-2022298116-A1
优先权日:2019-07-04
标题:Process for the preparation of key intermediates for the synthesis of eltrombopag or salt thereof

专利号:WO-2021001044-A1
优先权日:2019-07-04
标题 :Process for the preparation of key intermediates for the synthesis of eltrombopag or salt thereof

专利号:EP-3994126-A1
优先权日:2019-07-04
标 题 :Process for the preparation of key intermediates for the synthesis of eltrombopag or salt thereof