对氯苯乙腈置于氢氧化钾,氯化亚砜,硫酸,Tween-80体系中,用 吡啶,水,溶剂黄146,Xylene,苯 作为反应溶剂,化学反应生成 氰戊菊酯 参考文献:Synthesis Of 2-(3-Phenoxyphenyl)Isovaleric Acid And Its Esters Having Insecticidal Activity 标题:Synthesis Of 2-(3-Phenoxyphenyl)Isovaleric Acid And Its Esters Having Insecticidal Activity 摘要: DOI:10.1007/bf00956606
专利号:US-5443978-A 优先权日:1993-03-11 标 题 :Chrysanthemyl diphosphate synthase, corresponding genes and use in pyrethrin synthesis 发明人:ELLENBERGER SUZANNE R; PEISER GALEN D; BELL RUSSELL N; HUSSEY JR CHARLES E; SHATTUCK-EIDENS DONNA M; SWEDLUND BRADLEY D 权利人:AGRIDYNE TECH INC 摘要:This invention provides a purified chrysanthemyl diphosphate synthase (CDS), a method for the purification of CDS from Chrysanthemum cinerariaefolium, and an amino acid sequence of the isolated CDS. Also provided is a cDNA encoding the CDS, a nucleotide sequence of the CDS gene, and a derived amino acid sequence of the encoded CDS protein. The CDS gene is useful in the enzymatic production of the natural stereospecific configuration of chrysanthemyl derivatives which are useful for the synthesis of pyrethrins, pyrethroids, derivatives thereof, as well as other classes of metabolites.
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-2016073631-A1 优先权日:2013-03-04 标 题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
专利号:US-9233920-B2 优先权日:2010-06-11 标题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
专利号:US-10906880-B2 优先权日:2016-01-26 标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application 发明人:FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI 权利人:UNIV NANKAI 摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.
专利号:US-7825268-B2 优先权日:2003-12-23 标 题:Alkoxylactones, alkoxylactams and alkoxythiolactams for controlling processes based on microbial interaction 发明人:STUMPE STEFAN; BREVES ROLAND; HUCHEL URSULA; JANSSEN FRANK; HAETZELT ANDRE 权利人:HENKEL AG & CO KGAA 摘要:Compounds of the Formula I, n nwherein A 1 is O or NH; A 2 is O or S; each of R 1 and R 2 is independently hydrogen, a methyl or C 2 -C 8 -saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R 3 is a C 1 -C 18 -saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R 1 , R 2 and R 3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C 1 -C 6 -alkyl, trifluoromethyl, C 1 -C 6 -alkoxy, C 6 -C 10 -aryl, and C 1 -C 6 -alkyl-C 6 -C 10 -aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.
1: Lyu Z, Wang Q, Lu L, Xia X, Zhang L. [Research of fenvalerate induced neurodevelopmental toxicity by interfering with the action of estrogen]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Jul;32(7):487-92. Chinese. doi: 10.1016/j.pestbp.2014.12.004. Epub 2014 Dec 8. 4: Gill KK, Sandhu HS, Kaur R. Evaluation of lipid peroxidation and antioxidant status on fenvalerate, nitrate and their co-exposure in Bubalus bubalis. Pestic Biochem Physiol. 2015 Sep;123:19-23. doi: 10.1016/j.pestbp.2015.01.013. Epub 2015 Jan 22. doi: 10.1016/j.ttbdis.2015.03.003. Epub 2015 Apr 1. doi: 10.1016/j.pestbp.2016.01.003. Epub 2016 Jan 14. doi: 10.1093/chromsci/bmt133. Epub 2013 Sep 11. Chinese. doi: 10.2131/jts.41.255. doi: 10.1007/s00128-014-1261-2. Epub 2014 Apr 1. doi: 10.1080/03601234.2013.730299. doi: 10.1007/s12639-014-0562-z. Epub 2014 Sep 11. 14: Saxena PN, Gupta SK, Murthy RC. Comparative toxicity of carbaryl, carbofuran, cypermethrin and fenvalerate in Metaphire posthuma and Eisenia fetida -a possible mechanism. Ecotoxicol Environ Saf. 2014 Feb;100:218-25. doi: 10.1016/j.ecoenv.2013.11.006. Epub 2013 Dec 7. doi: 10.1007/s00204-012-0825-3. Epub 2012 Mar 22.
合成参考文献
参考文献:10.1002/arch.20437 摘要:Wang Z, Liu S, Yang B, Liu Z. Characterization of soluble and membrane-bound alkaline phosphatase in Nilaparvata lugens and their potential relation to development and insecticide resistance. Arch Insect Biochem Physiol. 2011 Sep;78(1):30–45. doi: 10.1002/arch.20437. 参考文献:10.3390/ijerph8062265 摘要:Mnif W, Hassine AI, Bouaziz A, Bartegi A, Thomas O, Roig B. Effect of endocrine disruptor pesticides: a review. Int J Environ Res Public Health. 2011 Jun;8(6):2265–303.