CAS: 5927-18-4; Methyl 2-(Dimethoxyphosphoryl)Acetate

上下游产品

methanol phosphonoacetic acid (2-chloro-2-ethoxy-vinyl)-phosphonic acid dichloride methyl chloroacetateDiazo(dimethoxyphosphoryl)essigsaeure(4-nitroanilid) methyl (E,E)-farnesoate methyl geranate (+/-)-methyl (E)-2,4,5-tetradecatrienoate

氯乙酸甲酯,亚磷酸二甲酯置于potassium Carbonate体系中,化学反应生成 三甲基膦酰基乙酸酯
参考文献:基于膦酰基乙酸的组成.合成与抗病毒活性
标题:基于膦酰基乙酸的组成.合成与抗病毒活性
摘要:开发了一种可生产的技术,该技术用于生产包含膦酰基乙酸的抗病毒组合物,在相转移条件下使亚磷酸二甲酯与亚磷酸二甲酯进行亚烷基的烷基化以及随后中间产物的原位水解.该组合物显示出针对由单纯疱疹病毒1和2和巨细胞病毒引起的疱疹病毒感染的表达的抗病毒作用.发现在有效浓度范围内的组合物对vero绿猴肾和м-19人二倍体细胞培养物没有细胞毒性作用.所得数据表明该组合物在实用医学中作为抗病毒剂和在卫生保健和食品生产设施中用于卫生的合成洗涤剂的抗病毒添加剂的潜在用途.
DOI:10.1134/s1070363215100394

专利信息

专利号:US-8642809-B2
优先权日:2007-09-25
标 题:Methods of synthesis of certain hydroxamic acid compounds
发明人：REISCH HELGE A; LEEMING PETER; RAJE PRASAD S
权利人:REISCH HELGE A; LEEMING PETER; RAJE PRASAD S; TOPOTARGET UK LTD
摘要:The present invention pertains to the general field of chemical synthesis, and more particularly to methods for the synthesis of certain hydroxamic acid compounds, and in particular, (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide, also known as PXD101 and Belinostat®, comprising, for example, the steps of: (SAF) sulfonamide formation; (PUR C ) optional purification; (AAA) alkenyl-acid addition, comprising: either (i): the steps of, in order: (ACAEA) alkenyl-carboxylic acid ester addition; (PUR E ) optional purification; and (CAD) carboxylic acid deprotection; or (ii): the step of: (ACAA) alkenyl-carboxylic acid addition; (PUR F ) optional purification; (HAF) hydroxamic acid formation; and (PUR G ) optional purification.

专利号:WO-0027627-A1
优先权日:1998-11-12
标题 :Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles
发明人：WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO
权利人:LILLY CO ELI; WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO
摘要:In its first aspect, the invention is directed to a solid support mediated method for the synthesis of diverse polycyclic heterocycles according to general formula (V). A second aspect of the invention is directed to a solid support bound intermediate compound that optionally can be derivatized before a cyclization and displacement procedure provides a product. The intermediate is preferably stable to a wide range of chemical conditions thus allowing, if desired, for the chemical derivatization of the intermediate. A third aspect of the invention is directed to a library of polycyclic heterocycle compounds where said library contains a plurality of diverse library compounds of general formula (V). A fourth aspect of the invention is directed to a method for the synthesis of a library of diverse polycyclic heterocycles by the general method described. A fifth aspect of the invention is directed to an assay kit for the identification of lead compounds of the library described therein.

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-9409945-B2
优先权日:1999-10-04
标 题 :Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
发明人：DESLONGCHAMPS PIERRE; DORY YVES; BERTHIAUME GILLES; OUELLET LUC; LAN RUOXI
权利人:OCERA THERAPEUTICS INC
摘要:A library of macrocyclic compounds of the formula (I) n n n n n n n n n n n n where part (A) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) y — bivalent radical or a covalent bond; n where part (B) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) z — bivalent radical, or a covalent bond; n where part (C) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) t — bivalent radical, or a covalent bond; and n where part (T) is a —Y-L-Z— radical wherein Y is CH 2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.

专利号:US-9802953-B2
优先权日:2007-10-03
标 题 :Intermediates and methods for the synthesis of halichondrin B analogs
发明人：CHASE CHARLES E; ENDO ATSUSHI; FANG FRANCIS G; LI JING
权利人:EISAI R&D MAN CO LTD
摘要:Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

专利号:US-6723853-B2
优先权日:2001-08-27
标 题 :Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
发明人：CURRAN DENNIS P; GABARDA ANA E
权利人:UNIV PITTSBURGH
摘要:A method of synthesizing a compound having the formula: n from a compound having the formula: n wherein R 1 is hydrogen, fluorine, chlorine or SiR 5 R 6 R 7 , wherein R 5 , R 6 , and R 7 are independently the same or different an alkyl group or an aryl group, R 2 is an alkyl group, R 3 is a protecting group, R 4 is an alkyl group, an allyl group, a propargyl group —CO 2 H, or a benzyl group, R 8 is —CO 2 R 10 , wherein R 10 is an alkyl group or an aryl group, X 1 is OH and X 2 is H, includes the step of exposing compound (III) to at least one of an organic acid or an inorganic acid. A compound has the general formula (III).