CAS: 59382-59-1; Methyl 2-Methyl-3-Nitrobenzoate

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CAS号67-56-1 甲醇 | CAS号1975-50-4 2-甲基-3-硝基苯甲酸 | CAS号74-88-4 碘甲烷 | CAS号23876-13-3 2-甲基-3-硝基苯甲醇 | CAS号89-71-4 邻甲基苯甲酸甲酯 | CAS号4637-24-5 N,N-二甲基甲酰胺二甲基缩醛 | CAS号39053-41-3 2-甲基-3-硝基苯甲酰氯 | CAS号7697-37-2 硝酸 | CAS号366452-97-3 4-硝基-异吲哚啉-1-酮 | CAS号39830-66-5 吲哚-4-羧酸甲酯 | CAS号366452-98-4 4-氨基异吲哚啉-1-酮 | CAS号220499-12-7 N-b°C-4-羟基甲基 吲哚 | CAS号220499-11-6 N-B°C-4-吲哚羧酸甲酯 | CAS号220499-13-8 4-溴甲基-1H-吲哚-1-羧... | CAS号82420-34-6 4-溴-2-硝基苄基溴 | CAS号83647-42-1 3-氨基-2-甲基苯甲醇 | CAS号82827-08-5 5-硝基异喹啉-1(2H)-酮 | CAS号98475-07-1 2-溴甲基-3-硝基苯甲酸甲酯

2-甲基-3-硝基苯甲酸 反应生成 2-甲基-3-硝基苯甲酸甲酯
参考文献:Novel Cyclic Amide Derivatives
标题:Novel Cyclic Amide Derivatives
摘要:以下公式(i)表示的新化合物作为sigma受体/结合位点的配体,并包括作为活性成分的药物: 其中x代表烷基,芳基,杂环基或类似基团;q代表由-ch 2-,-co-,-o-,-ch(Or 7)-或类似基团表示的基团,其中r 7 代表氢原子,烷基或类似基团;n代表从0到5的整数;r 1 和r 2 各自代表氢原子,烷基或类似基团;b代表以下任一基团: 其中r 3,R 4,R 5 和r 6 各自代表氢原子,卤素原子,烷氧基或类似基团;m代表1或2;以及: 代表芳香杂环环.

专利信息

专利号:US-10392364-B2
优先权日:2014-08-11
标题:Process for synthesis of lenalidomide
发明人：RAO RAMAKRISHNA; NANDIPATI RAMADEVI; GOODA RAVI; SHEWALKAR MUKESH PADMAKAR; BHADKE VENKAT VASANTRAO
权利人:AVRA LABORATORIES PVT LTD
摘要:Disclosed herein is an improved process for preparation of Lenalidomide and crystalline polymorphic forms thereof.

专利号:WO-2022222272-A1
优先权日:2021-04-19
标 题 :Synthesis process of 2-methyl-3-methoxybenzoic acid
发明人：GENG JINGKUN; Fang Zheneng; YAO LINXI; JI PINJUN; ZHANG YANCHAO; MIAO JUNHUI; WANG BOTAO
权利人:JIANGSU YONGAN CHEMICAL CO LTD
摘要:Disclosed is a synthesis process of 2-methyl-3-methoxybenzoic acid. The synthesis process comprises the following steps: (1) a reductive hydrogenation reaction, involving: using 2-methyl-3-nitrobenzoic acid or methyl 2-methyl-3-nitrobenzoate as a raw material, methanol as a solvent, hydrogen as a hydrogen source and palladium on carbon or platinum on carbon as a catalyst to prepare 3-amino-2-methylbenzoic acid or methyl 3-amino-2-methylbenzoate by means of hydrogenation reduction; (2) a one-pot reaction of diazotization, hydrolysis and esterification, involving: using the reduction product as a raw material and methanol as a solvent to prepare methyl 3-hydroxy-2-methylbenzoate by means of diazotization, hydrolysis and esterification reactions under the action of a diazotization reagent; (3) a methylation reaction, involving: using methyl 3-hydroxy-2-methylbenzoate as a raw material and dimethyl sulfate as a methylation reagent to prepare methyl 3-methoxy-2-methylbenzoate by means of a methylation reaction in the presence of an alkali; and (4) a hydrolysis reaction, involving: mixing methyl 3-methoxy-2-methylbenzoate with an alkali and water, and heating same for hydrolysis, cooling same after the reaction is completed, adjusting the pH to 1-3 with an acid to precipitate a product, followed by filtering and drying same to obtain 3-methoxy-2-methylbenzoic acid.

专利号:US-2018334443-A1
优先权日:2014-08-11
标题:An improved process for synthesis of lenalidomide

专利号:US-9522899-B2
优先权日:2009-06-01
标 题:Methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2, 6-dioxopiperidine, and intermediates thereof
发明人：YAN RONG; YANG HAO; XU YONGXIANG
权利人:NANJING CAVENDISH BIO-ENGINEERING TECH CO LTD; YAN RONG; NANJIAN CAVENDISH BIO-ENGINEERING TECH CO LTD
摘要:The present invention discloses methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2,6-dioxopiperidine and intermediates thereof, namely, the synthesis of compounds of the Formula (I), with each substitutional group defined in the patent specification. Owing to the advantages of high productivity, little influence to the environment and material accessibility, the methods of the present invention is suitable for industrial production.

专利号:WO-2016024286-A2
优先权日:2014-08-11
标 题 :An improved process for synthesis of lenalidomide

专利号:US-2003139451-A1
优先权日:2001-08-06
标题 :Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs