CAS: 6306-52-1; H-Val-Ome.Hcl

相似化合物

7146-15-8 154674-67-6 4070-48-8

上下游产品

CAS号67-56-1 甲醇 | CAS号72-18-4 l-缬氨酸 | CAS号17498-50-9 L-缬氨酸盐酸盐 | CAS号13734-41-3 B°C-L-缬氨酸 | CAS号78342-42-4 (S)-2,5-二氢-3,6-... | CAS号852994-84-4 (3S)-N-1-(tert-... | CAS号835596-02-6 (3S,6S)-3-chlor... | CAS号482577-59-3 N-[(2'-氰基联苯-4-基... | CAS号18830-14-3 2-[(3-benzylsul... | CAS号21285-27-8 L-Valine,1-[(ph... | CAS号72-18-4 l-缬氨酸 | CAS号24210-19-3 (S)-2-(((苄氧基)羰基... | CAS号30293-86-8 (S)-(-)-2-异氰酰基-... | CAS号79069-14-0 N-B°C-L-缬氨醇 | CAS号78603-95-9 (S)-(-)-2-氨基-3-... | CAS号58561-04-9 N-(叔丁氧基羰基)-L-缬氨酸甲酯 | CAS号157035-77-3 (S)-3-(B°C-氨基)-...

L-缬氨酸置于氯化亚砜体系中,化学反应生成 L-缬氨酸甲酯盐酸盐
参考文献:用非编码α-氨基异丁酸的模型肽进行β-转角开放的研究
标题:用非编码α-氨基异丁酸的模型肽进行β-转角开放的研究
摘要:单晶x射线衍射研究表明,在三个末端受保护的模型三肽i-Iii中,Boc-Ile-Aib-Xx-Ome(肽i中的xx :Val;ii:Leu;iii:Phe)具有非中心位置编码的氨基酸aib(aib:α-氨基异丁酸),肽段i对β-Turn显示构象偏好,肽段ii形成水合的β-Turn,代表溶剂介导的中间体,用于β-Turn和β-Strand之间的相互转化和肽iii采用完全展开的β链状结构.通过改变第三残基的空间体积xx(3),已分离出与β-转角和β-链之间的结构互变有关的各种构象.溶液相中的肽构象已通过溶剂依赖性NMR滴定和cd光谱法进行了探测.扫描电子显微镜(sem)的形态学研究表明,在三种肽中,只有肽iii可以形成固态的丝状原纤维.
DOI:10.1016/j.Tet.2007.07.075

专利信息

专利号:US-6423871-B1
优先权日:1999-02-26
标题 :Efficient synthesis of secondary amines by selective alkylation of primary amines
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23° C.; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73% yield.

专利号:US-4111933-A
优先权日:1976-04-30
标题:Protection of functional groups during reaction and their subsequent restoration
发明人：ECKERT HEINER; UGI IVAR; KABBE HANS-JOACHIM
权利人:BAYER AG
摘要:In the process for preparing an organic compound of the formula n n A' -- X n n in which n X is an amino group, a hydroxyl group or a carboxyl group, and n A' is the remainder of the molecule, from an organic compound of the formula n n A -- X n n in which n A is the remainder of the molecule which can undergo reaction to form A', by converting A -- X into a compound of the formula n n A -- Z -- COOR n n in which n Z is --NH--, --O-- or a direct C--C bond, and n R is a radical of the formula ##STR1## IN WHICH Y is a direct C--C single bond, the --CHâ•?CH-- group or an arylene group, n R 1 to R 4 each independently is hydrogen, halogen or an alkyl, aryl, aralkyl, alkoxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl or cycloalkylaminocarbonyl radical, or n R 1 + r 2 and R 3 + R 4 each independently completes a 5- or 6-membered carbocyclic ring, or n R 1 and R 3 conjointly with the grouping --C--Y--C-- forms a carbocyclic ring with 5 or 6 carbon atoms, and Hal is halogen, n Thereby to protect X, then converting A -- Z -- COOR into a compound of the formula n n A' -- Z -- COOR n n and then treating the compound A' -- Z -- COOR to restore the group X, the improvement which comprises effecting the treatment of the compound A' -- Z -- COOR with an alkali metal compound of a complex of monovalent cobalt. The process is applicable particularly to aminocarboxylic acids including intermediates from various stages of the synthesis of penicillins and cephalosporis.

专利号:US-2020181095-A1
优先权日:2017-06-06
标题:Selective matrix metalloproteinase-13 inhibitors
发明人：FIELDS GREGG B; ROUSH WILLIAM R; CHOI JUN YONG; FUERST RITA
权利人:FLORIDA ATLANTIC UNIV BOARD OF TRUSTEES; SCRIPPS RESEARCH INST
摘要:We describe the use of comparative structural analysis and structure-guided molecular design to develop potent and selective inhibitors (10d and (S)-17b) of matrix metalloproteinase 13 (MMP-13). We applied a three-step process, starting with a comparative analysis of the X-ray crystallographic structure of compound 5 in complex with MMP-13 with published structures of known MMP-13 inhibitor complexes followed by molecular design and synthesis of potent, but non-selective zinc-chelating MMP inhibitors (e.g., 10a and 10b). After demonstrating that the pharmacophores of the chelating inhibitors (S)-10a, (R)-10a, and 10b were binding within the MMP-13 active site, the Zn2+ chelating unit was replaced with non-chelating polar residues that bridged over the Zn2+ binding site and reach into a solvent accessible area. After two rounds of structural optimization, these design approaches led to small molecule MMP-13 inhibitors 10d and (S)-17b which bind within the substrate-binding site of MMP-13 and surround the catalytically active Zn2+ ion without chelating to the metal. These compounds exhibit at least 500-fold selectivity versus other MMPs.

专利号:EP-1831186-B1
优先权日:2004-11-30
标题:A process for the synthesis of valsartan
发明人：ZUPANCIC SILVO; PECAVAR ANICA; ZUPET ROK
权利人:KRKA D D NOVO MESTO
摘要:This invention relates to an improved process for preparing a valsartan, or a pharmaceutically acceptable salt thereof, or pharmaceutical preparation containing either entity wherein a compound of formula (II) nor a salt thereof, is reacted with valine or an ester or a salt thereof in a solvent selected from the group consisting of methylene chloride, chloroform, butyl chloride, isopropyl acetate and tert -butyl methyl ether to form a compound of formula (IV) nwhich is then acylated to form a compound of formula (VI) nwherein R is hydrogen, alkyl, alkenyl or benzyl; which is then deprotected to give valsartan, and may be converted to a pharmaceutically acceptable salt and/or a pharmaceutical formulation. The invention also covers intermediates of formula (IV) and (VI) wherein R=H.

专利号:US-9845299-B2
优先权日:2013-01-14
标 题 :Process for the preparation of a fluorolacton derivative
发明人：CHEN RONGMIN; LI YUANQIANG; ZHAO JIANQIANG; ZHENG JIANBING; ZHU GUOLIANG
权利人:GILEAD PHARMASSET LLC
摘要:A novel process for the preparation of a fluorolactone derivative of the formula n n n n n n n n n n n n and of its acylated derivative of formula n n n n n n n n n n n n n n n n wherein R 1 stands for a hydroxy protecting group is described. n n n n n The acylated fluor lactones of formula V, particularly the benzoyl derivative with R 1 =benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.

专利号:US-3725380-A
优先权日:1969-04-05
标 题:Method of synthesizing peptides in the presence of a carbodiimide and a 1-hydroxy-benzotriazole
发明人：KONIG W; GEIGER R
权利人:HOECHST AG
摘要:Improved synthesis of peptides by the carbodiimide method in which an amino-protected amino acid or peptide having a reactive carboxy group is condensed with a carboxy-protected amino acid or peptide having a reactive amino group in the presence of a 1hydroxy-benzotriazole or a substituted 1-hydroxy-benzotriazole of the formula AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.