CAS: 947-19-3; (1-Hydroxycyclohexyl)(Phenyl)Methanone

• 英文名称(1-Hydroxycyclohexyl)(Phenyl)Methanone
• 中文名称1-羟环己基苯酮
• IUPAC名称(1-hydroxycyclohexyl)(phenyl)methanone
• 其它别名光引发剂184; 1羟基环己基苯甲酮; Photoinitiator-184
• CAS编号947-19-3
• MFCD编号:MFCD00059561
• EINECS号:213-426-9
• FDA UNII编号:E7JVN2243X
• 分子式:C13H16O2
• 分子量:204.27
• 产品CID: 1999392
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• 产品信息参考
• InChIKey: QNODIIQQMGDSEF-UHFFFAOYSA-N
• InChI=1S/C13H16O2/c14-12(11-7-3-1-4-8-11)13(15)9-5-2-6-10-13/h1,3-4,7-8,15H,2,5-6,9-10H2…
• 计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数2.0

物理性质

• 熔点47-50°C
• 沸点339°C at 760 mmHg
• 闪点164°C
• 密度1.1±0.1 g/cm3
• pKa:13.23±0.20(预测)
• PSA:37.3
• LogP:2.5645
• 折射率1.571
• 蒸汽压0.0±0.8 mmHg at 25°C
• 溶解性Acetonitrile (Slightly), Chloroform (Slightly)
• 敏感性常温常压下稳定，避免氧化物接触
• 外观形态白色至类白色固体
• 储存条件惰性气氛,室温
• 产品应用高效光引发剂,用于紫外固化体系,能使其长期不泛黄和延长储存.

MSDS等安全信息

• GHS象形图
• GHS符号GHS08;
  注释: Health hazard
• 危险类别生殖毒性 类别1B
  水生慢性毒性 类别3
  急性毒性 类别4(吸入)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  急性毒性 类别2(吸入)
• 警示词Danger(危险)
• 危险描述H360F |可能损害生育能力.
  H412 |对水生生物有害并具有长期持续影响.
  H332 |吸入有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H330 |吸入致命.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• UN编号NONH for all modes of transport
• 危险品标志Xi
• 安全声明26-24/25
• 危险类别码36
• WGK Germany-

欧盟法规

上下游产品

合成工艺路线路线简述

• 1135-71-3 = 947-19-3
  反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Tetrabutylammonium Bromide Solvents: Water; Rt -> 105 °C
  标题:Preparation Of Photoinitiator 184 By Alkaline Hydrolysis Method
  参考文献:China]
  
  1135-72-4 = 947-19-3
  反应条件:1.1 Reagents: Potassium Bromide,Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Solvents: Acetonitrile,Water; 1 H,70 °C
  标题:Oxidation Of Primary Alcohols And Aldehydes To Carboxylic Acids Via Hydrogen Atom Transfer
  作者:Tan,Wen-Yun; Lu,Yi; Zhao,Jing-Feng; Chen,Wen; Zhang,Hongbin
  参考文献:Organic Letters 日期:2021 卷标:23(17) 页码:6648-6653]
  
  37545-92-9 = 947-19-3
  反应条件:1.1 Reagents: Oxygen; 0.8 Mpa,Rt; 1 Mpa,Rt -> 80 °C; 8 - 12 H,1 Mpa,80 °C
  标题:Process For Preparation Of Aromatic α-Hydroxy Ketones
  参考文献:China]
  
  712-50-5 = 947-19-3
  反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Acetonitrile,Water; Rt; Rt -> 110 °C; 16 H,110 °C
  标题:Photocatalytic Synthesis Method Of 1-Hydroxycyclohexyl Phenyl Ketone And Its Application
  参考文献:China]
  
  712-50-5 = 947-19-3
  反应条件:1.1 Reagents: Tert-Butyl Peroxide Solvents: Dichloromethane; 50 °C1.2 Reagents: Sodium Bisulfite Solvents: Water; Rt
  标题:Ultrasonic Preparation Method Of α-Hydroxy Ketone
  参考文献:China]
  
  56345-98-3 = 947-19-3
  反应条件:1.1 Reagents: Sodium Acetate Solvents: Water
  标题:Trifluoromethanesulfonic (Triflic) Acid Catalyzed Transformations Of α-Hydroxy Carbonyl Compounds
  作者:Olah,George A.; Wu,An Hsiang
  参考文献:Journal Of Organic Chemistry 日期:1991 卷标:56(7) 页码:2531-4]
  
  712-50-5 = 947-19-3
  反应条件:1.1 Reagents: Chlorine Solvents: Water; 1.5 H,70 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; 4.5 H,90 °C
  标题:Synthesis Of Photoinitiator 1-Hydroxycyclohexyl Phenyl Ketone
  参考文献:China]
  
  712-50-5 = 947-19-3
  反应条件:1.1 Reagents: Chlorine; 20 Min,1 - 2 Atm,55 - 60 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; 10 Min,50 °C
  标题:Method For Preparing α-Hydroxyketone Compounds In Microreactor
  参考文献:China]
  
  65-85-0 + 98-89-5 = 947-19-3
  反应条件:1.1 Catalysts: Manganese Benzoate; 280 °C; 6 - 24 H,280 °C1.2 Reagents: Chlorine; 50 - 80 °C1.3 Reagents: Sodium Hydroxide Solvents: Water
  标题:Continuous Green Preparation Of Photoinitiator Uv-184 By Condensation Method
  参考文献:China]
  
  712-50-5 = 947-19-3
  反应条件:1.1 Reagents: Triethyl Phosphite,Cesium Carbonate Solvents: Dimethyl Sulfoxide; 72 H,25 °C1.2 Reagents: Ethyl Acetate
  标题:Preparation Of α-Hydroxycarbonyl Compound
  参考文献:China]
  
  712-50-5 = 947-19-3
  反应条件:1.1 Reagents: Triethyl Phosphite,Oxygen Catalysts: Cesium Carbonate Solvents: Dimethyl Sulfoxide; 72 H,1 Atm,25 °C
  标题:Highly Efficient C-H Hydroxylation Of Carbonyl Compounds With Oxygen Under Mild Conditions
  作者:Liang,Yu-Feng; Jiao,Ning
  参考文献:Angewandte Chemie 日期:2014 卷标:53(2) 页码:548-552]
  
  1135-72-4 = 947-19-3
  反应条件:1.1 Reagents: Potassium Bromide,Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Solvents: Acetonitrile,Water; 1 H,70 °C; 70 °C -> Rt1.2 Reagents: Sodium Sulfite Solvents: Water; Rt
  标题:Oxidation Of Primary Alcohols And Aldehydes To Carboxylic Acids With 1-Hydroxycyclohexyl Phenyl Ketone
  作者:Lu,Yi; Tan,Wen-Yun; Ding,Yuzhen; Chen,Wen; Zhang,Hongbin
  参考文献:Journal Of Organic Chemistry 日期:2023 卷标:88(13) 页码:8114-8122]
  
  931-97-5 + 1623-99-0 = 947-19-3
  反应条件:1.1 Solvents: Tetrahydrofuran; -5 °C; 2 H,Rt
  标题:Preparation Method Of Hydroxyalkyl Phenyl Ketone Compounds
  参考文献:China]
  
  1135-72-4 = 947-19-3
  反应条件:1.1 Reagents: Tetramethylammonium Hydroxide Pentahydrate Catalysts: 1,10-Phenanthroline,Cuprous Chloride Solvents: Toluene; 10 - 20 Min,Rt; Rt; 5 Min,Rt1.2 Reagents: Oxygen; Rt; 30 Min,Rt -> 70 °C
  标题:Oxidative Process And Catalysts For Converting Alcohols Into Carbonyl Compounds
  参考文献:World Intellectual Property Organization]
  
  1135-71-3 = 947-19-3
  反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Tetrabutylammonium Bromide Solvents: Water; 85 °C
  标题:Preparation Of 1-Hydroxycyclohexyl-Phenylmethanone By Alkaline Hydrolysis
  参考文献:China]
  
  7500-66-5 = 947-19-3
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 4.5 H,70 °C1.2 Reagents: Acetic Acid; Neutralized
  标题:New Process For Synthesizing 1-Hydroxycyclohexylphenylketone
  作者:Xia,Jun; Wu,Jian; Luo,Hean; Wang,Liangjie
  参考文献:Huagong Shikan 日期:2004 卷标:18(8) 页码:49-50]
  
  712-50-5 = 947-19-3
  反应条件:1.1 Reagents: Carbon Tetrachloride,Sodium Hydroxide Catalysts: Tetrabutylammonium Bromide; 12 H,80 - 90 °C
  标题:Process For Preparation Of Photoinitiator 184
  参考文献:China]
  
  24731-36-0 = 947-19-3
  反应条件:1.1 Catalysts: Iodine Solvents: Diethyl Ether
  标题:Conversion Of Ketone Trimethylsilylcyanohydrins To Several Types Of Compounds
  作者:Ohta,Shunsaku; Yamashita,Masayuki; Arita,Kazuo; Kajiura,Takahiro; Kawasaki,Ikuo; Et Al
  参考文献:Chemical & Pharmaceutical Bulletin 日期:1995 卷标:43(8) 页码:1294-301]
  
  = 947-19-3
  反应条件:1.1 Catalysts: Magnesium Solvents: Dimethylformamide; -20 °C; 2 H,-20 - -10 °C; -10 °C -> Rt1.2 Reagents: Sodium Hydroxide Catalysts: Tetrabutylammonium Bromide Solvents: Water; 2 H,Rt -> 50 °C
  标题:Method For Preparation Of α-Hydroxyketone Photoinitiator
  参考文献:China]
  
  712-50-5 = 947-19-3
  反应条件:1.1 Reagents: Hydrochloric Acid,Hydrogen Peroxide Solvents: 1,1-Dichloroethane,Water; 45 °C; 45 - 50 °C; 1 H,50 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; 4 H,57 - 60 °C; 5 H,57 - 60 °C
  标题:Synthesis Method Of Photoinitiator 1-Hydroxycyclohexyl Phenyl Ketone
  参考文献:China

海关参考信息

• 2902600000-乙苯
  2905122000-异丙醇
  2905143000-叔丁醇
  2912110000-甲醛
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• ➥ 防范代码详解
• ➥ 危险代码说明
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