CAS: 109-72-8; Butyllithium

上下游产品

CAS号109-65-9 正溴丁烷 | CAS号2744-08-3 顺式十氢异喹啉 | CAS号109-69-3 1-氯丁烷 | CAS号629-35-6 dibutylmercury | CAS号1643-19-2 四丁基溴化铵 | CAS号917-64-6 甲基碘化镁 | CAS号62735-89-1 2-chloro-1,1,3,... | CAS号7439-93-2 金属锂 | CAS号60-29-7 乙醚 | CAS号10457-58-6 14-Butyldibenz[... | CAS号102673-72-3 3-butylidene-4-... | CAS号10385-08-7 Heptanamide,N,N... | CAS号106107-48-6 6-(叔丁氧基羰基氨基)-2,... | CAS号10557-66-1 dibutylphosphor... | CAS号4233-13-0 [butyl(phenyl)p... | CAS号71521-86-3 1-butyl-2-penty... | CAS号110349-15-0 1-iodo-2-pentyl... | CAS号1052114-83-6 5-溴-4-羟基烟酸

正溴丁烷置于lithium体系中,用 乙醚 用作溶剂,化学反应生成正丁基锂
参考文献:合成季铵脂质及其前体鏻盐的抗革兰氏阳性菌活性
标题:合成季铵脂质及其前体鏻盐的抗革兰氏阳性菌活性
摘要:有机铵盐和磷盐通过与细菌膜发生致命的相互作用而发挥优异的抗菌作用.特别是,季铵脂质已证明作为基因载体和抗菌剂的有效性.在这里,为了寻找属于这两类的新抗菌装置,我们通过设计合成路径来制备水溶性季铵脂质 (6) 和鏻盐 (1),其中 1 是实现 6 的中间体.所有合成的化合物通过傅里叶变换红外光谱和核磁共振对其进行了表征.此外,对 Nh3+ 基团 1 和 6 进行电位滴定,通过测定其实验分子量来进一步确认其结构.首先针对一系列革兰氏阳性和革兰氏阴性菌种的多重耐药临床分离株评估了1和6的抗菌活性,观测到这两种化合物对肠球菌属和葡萄球菌属的革兰氏阳性分离株具有显着的抗菌活性.对这些物种的更广泛菌株的进一步研究证实了 1 和 6 的显着抗菌作用(mic 分别为 4-16 和 4-64 µg/ml),而 1 进行的 24 小时杀菌实验不同的金黄色葡萄球菌分离株表现出抑菌行为.此外,化合物1和6在较低的
Doi:10.3390/ijms25052761

专利信息

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

专利号:US-11661406-B2
优先权日:2018-08-13
标 题 :Method for producing intermediate useful for synthesis of SGLT inhibitor
发明人：LI QING RI; YOON HEE KYOON
权利人:DAEWOONG PHARMACEUTICAL CO LTD
摘要:A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-6184168-B1
优先权日:1997-09-22
标题:Synthesis of 1,4-trans-polybutadiene using a lanthanide organic acid salt catalyst
发明人：LYNCH THOMAS J
权利人:BRIDGESTONE CORP
摘要:The invention provides a catalyst composition, comprising: (a) an organolithium compound; and, (b) an organic acid salt of lanthanide series element; wherein: (1) only components (a) and (b) are required to promote the synthesis of 1,4-trans-polybutadiene; (2) the ratio of component (a) to component (b) is selected to maximize formation of the trans structure of said 1,4-trans-polybutadiene; and, (3) components (a) and (b) are selected for enabling further diblock synthesis. The invention further contemplates a process for using the catalyst to synthesize 1,4-trans-polybutadiene and other polymers and copolymers having trans configuration in the conjugated diene monomer contributed units.

专利号:US-4351767-A
优先权日:1981-06-29
标题 :Synthesis of 24,25-dihydroxycholesterol
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. More particularly, the invention pertains to the synthesis of 24,25-dihydroxycholesterol. It includes intermediate sterols of this synthesis and processes for their preparation.

专利号:US-2008086013-A1
优先权日:2006-06-15
标 题:Carbometallation of alkynes and improved synthesis of uniquinones
发明人：LIPSHUTZ BRUCE H
权利人:UNIV CALIFORNIA
摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.