CAS: 183905-31-9; (S)-1-Acetamido-3-Chloropropan-2-Yl Acetate

相似化合物

169048-79-7 53460-78-9 3920-11-4

上下游产品

acetic anhydride (S)-1-amino-3-chloropropan-2-ol (2S)-1-amino-3-chloropropan-2-ol hydrogen chloride (S)-1-amino-3-chloro-2-propanol hydr°Chloride benzyl 7-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate phenylmethyl-7-{5-[(acetamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2H,3H,4H,5H-benzo[f]azaperhydroepinecarboxylate benzyl 7-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-1,3,4,5-tetrahydro-3H-2-benzazepine-2-carboxylate N-[((5S)-3-{4-[(1α,5α,6β)-3-(4-methoxybenzyl)-3-azabicyclo[3.1.0]hex-6-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide

乙酸酐,(S)-1-氨基-3-氯-2-丙醇盐酸盐置于吡啶体系中,用 二氯甲烷 用作溶剂,化学反应 20.0H,以90.6%的收率获得(S)-N-[2-乙酰氧基-3-氯丙基]乙酰胺acetamide
参考文献:利伐沙班及其中间体的制备方法
标题:利伐沙班及其中间体的制备方法
摘要:本发明公开了一种通过一个中间体式(5)制备利伐沙班新的方法,所述方法包括通过酰化修饰式(2)S‑1‑氨基‑3‑氯‑2‑丙醇得到式(3),再在碱催化与式(4)4‑(3‑氧代吗啉酮基)苯胺甲酰苄酯反应,以高产率的提供式(5)的结构,该中间体经酸水解制得式(6)4‑{4‑[(5S)‑5‑(氨基甲基)‑2‑氧代‑1,3‑恶唑烷‑3‑基]苯基‑吗啉‑3‑酮,最后与式(C)5‑氯噻吩‑2‑甲酰氯反应制得利伐沙班,本发明利伐沙班的制备方法具反应收率高,便于提纯,反应条件温和,操作简便等优点,在合成过程中虽然需要酰化修饰,但是产率有明显提高,而且可以简化提纯过程,适合于工业化生产.

专利信息

专利号:US-9233989-B2
优先权日:2011-10-11
标题:Sila analogs of oxazolidinone derivatives and synthesis thereof
发明人：REDDY DUMBALA SRINIVASA; BALAMKUNDU SEETHARAM SINGH; RAMESH REMYA
权利人:COUNCIL SCIENT IND RES
摘要:The invention discloses silaanalogs of oxazolidinone compounds, to pharmaceutical compositions and to the synthesis of the oxazolidinone derivatives of formula I. The invention further relates to methods of treating a subject suffering with gram positive pathogens including those resistant to methicillin and vancomycin using the compound(s) or modulation of coagulation properties of blood-clotting cascade or compositions of the oxazolidinone derivatives of the invention.

专利号:WO-2013046211-A1
优先权日:2011-09-27
标 题 :Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.

专利号:CN-108707080-B
优先权日:2018-06-20
标 题:A kind of environment-friendly synthesis method of linezolid and intermediate thereof

专利号:US-2014296133-A1
优先权日:2011-10-11
标题:Sila analogs of oxazolidinone derivatives and synthesis thereof

专利号:WO-2013054275-A1
优先权日:2011-10-11
标题:Sila analogs of oxazolidinone derivatives and synthesis thereof

专利号:EP-2766373-B1
优先权日:2011-10-11
标题:Sila analogs of oxazolidinone derivatives and synthesis thereof