CAS: 19947-39-8; 3-Amino-3-(4-Chlorophenyl)Propanoic Acid

上下游产品

malonic acid 4-chlorobenzaldehyde 3-(4-Chloro-phenyl)-3-hydroxyamino-propionic acid 3-(4-chlorophenyl)prop-2-enoic acid 3-amino-3-(4-chlorophenyl)propionic acid methyl ester hydr°Chloride 3-(4-Chloro-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionic acid β-(N-phenylacetylamino)-β-(4-chlorophenyl)propionic acid 3-[3N'-(2-chloroethyl)ureido]-3-(4-chlorophenyl)propionic acid

对氯肉桂酸置于sodium Hydroxide,盐酸羟胺,Sodium Ethanolate,锌体系中,用 乙醇,水 用作溶剂,化学反应 24.0H,反应生成3-氨基-3-(4-氯苯基)丙酸
参考文献:Potential Gaba B Receptor Antagonists. Ix The Synthesis Of 3-Amino-3-(4-Chlorophenyl)Propanoic Acid,2-Amino-2-(4-Chlorophenyl)Ethylphosphonic Acid And 2-Amino-2-(4-Chlorophenyl)Ethanesulfonic Acid
标题:Potential Gaba B Receptor Antagonists. Ix The Synthesis Of 3-Amino-3-(4-Chlorophenyl)Propanoic Acid,2-Amino-2-(4-Chlorophenyl)Ethylphosphonic Acid And 2-Amino-2-(4-Chlorophenyl)Ethanesulfonic Acid
摘要:本文介绍了 3-氨基-3-(4-氯苯基)丙酸以及相应的膦酸和磺酸的合成过程. 以及相应的膦酸和磺酸的合成. 巴氯芬,法氯芬和沙氯芬的低级同系物.氯化酸都是置于gabab 受体上是 Gaba 的弱特异性拮抗剂,磺酸(pa2 4-0)强于膦酸(pa2 4-0). 强于膦酸(pa2 3-8)和羧酸(pa2 3-5 酸(pa2 3-5)更强.
Doi:10.1071/c96216

专利信息

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-5892038-A
优先权日:1997-12-08
标 题 :Hydroxy-amino acid amides
发明人：DOLLE III ROLAND ELLWOOD; PATEL HITESH K
权利人:PHARMACOPEIA INC
摘要:Compounds of Formula I I are disclosed as inhibitors of plasmepsin and cathepsin D. The compounds are therefore useful to treat diseases such as malaria. In preferred compounds of formula I, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or a substituted piperazinealkanoic acid. Intermediates in the solid phase synthesis of compounds of formula I, in which the compounds are attached to a solid support, are also disclosed.