CAS: 26367-48-6; (E)-Ethyl 4-Chloro-4-Oxobut-2-Enoate

该化合物是有机化合物,其特性为功能组,包括氯化碳基和酯酸,该化合物一般是无色的,可粉黄液,并因其在丙烯酸结构中存在碳基和双联体而具有回活动性而闻名;可溶于有机溶剂,使其在各种化学反应中有用,特别是在合成较复杂的分子方面.氯化碳基酸组可参与核生殖反应,而丙烯酸组可进行聚合,该化合物可用于生产农用化学品,制药或有机合成的中间体.安全考虑因素包括在通风良好的地区处理该化合物,并使用适当的个人防护设备,因为接触时可能对健康造成危害.

英文名称(E)-Ethyl 4-Chloro-4-Oxobut-2-Enoate
中文名称(E)-4-氯-4-氧代丁-2-烯酸乙酯
IUPAC名称ethyl (E)-4-chloro-4-oxobut-2-enoate
其它别名Ethyl (E)-3-Chlorocarbonylacrylate ; Ethyl (E)-4-Chloro-4-Oxobut-2-Enoate ; Ethyl 4-Chloro-4-Oxobut-2-Enoate ; (E)-3-Chlorocarbonyl Acrylic Acid Ethyl Ester ; Ethyl Fumaryl Chloride ; Ethyl (2E)-4-Chloro-4-Oxobut-2-Enoate ; (E)-3-(Chloroformyl)-Acrylic Ac
CAS编号26367-48-6
MFCD编号:MFCD03002066
EINECS号:628-424-7
分子式:C6H7ClO3
分子量:162.57
产品CID: 1237078
产品分类有机原料→分子砌块→脂肪链类化合物

相似结构搜索
InChIKey: YYLWXDIGYFPUSK-ONEGZZNKSA-N
InChI=1S/C6H7ClO3/c1-2-10-6(9)4-3-5(7)8/h3-4H,2H2,1H3/b4-3+…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数4.0

相似化合物

2960-66-9 2459-05-4 141-05-9

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05 & GHS08;
注释: Exclamation mark & Corrosion & Health hazard
危险类别急性毒性类别4(经口)
皮肤腐蚀类别1B
呼吸道致敏类别1
皮肤致敏类别1
特定目标器官毒性 - 单次接触类别3
警示词Danger(危险)
危险描述H302 |吞咽有害.
H314 |造成严重皮肤灼伤和眼损伤.
H334 |吸入可能引起过敏或哮喘症状或呼吸困难.
H317 |可能引起皮肤过敏反应.
H335 |可能引起呼吸道刺激.
防范说明P260-P261-P264-P270-P272-P280-P284-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P330-P362+P364-P363-P405-P501
危险等级8
UN编号3265.0
危险品标志C
包装等级Ⅱ
安全声明26-36/37/39-45
危险类别码22-34-43
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

富马酸单乙酯置于4-二甲氨基吡啶,草酰氯体系中,用二氯甲烷用作溶剂,化学反应 1.5H,以93%的收率获得富马酸单乙酯酰氯
参考文献:亲二烯体对diels的反应性的调节通过α,β-不饱和螯合物的络合进行的der木反应
标题:亲二烯体对diels的反应性的调节通过α,β-不饱和螯合物的络合进行的der木反应
摘要:我们描述亲二烯体为反应性的调制狄尔斯阿尔德反应通过基于螯合定位成邻近其cc键的酰胺的新原理.已证明具有三种不同螯合实体的改性丙烯酸衍生物和相关的亲二烯体.螯合剂导致强化的吸电子效应导致的反应性在增强的络合狄尔斯阿尔德取决于复合金属离子反应.这种新方法的应用可能会扩展到与螯合酰胺相邻的反应实体进行的其他反应.
Doi:10.1002/hlca.201400224

海关参考信息

2901210000-乙烯
2901220000-丙烯
2909110000-乙醚
2912110000-甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2009018343-A1
优先权日:2005-03-16
标题 :Fluorous Oxazolidinone Chiral Auxiliary Compounds and Methods of Manufacture
发明人：HULTIN PHILIP GREGORY; HEIN JASON ELLIS
权利人:UNIV MANITOBA
摘要:The present invention relates generally to perfluoroalkyl chiral auxiliary compounds and methods of manufacture. These compounds have the functionality to effectively support the synthesis of chiral compounds in single reactions, high-throughput parallel reactions, or combinatorial reactions The invention relates to two oxazolidinone chiral auxiliaries (1) and (2): wherein R f is a perfluoroalkyl group having the general formula (CH 2 ) x â€”C y F 2y+1 where x=1-5 and y=4-10 and wherein B is an unfunctionalized aryl, alkyl or arylalkyl group in a preferred embodiment, x=2 and y=6 and B is derived from unfunctionalized amino acids The amino acids may be from either the D- or L-series, and are preferably enantiomerically pure or in very high enantiomeric excess in either configuration.

专利号:US-9944669-B2
优先权日:2014-03-21
标题:Fumarate-CO-releasing molecule hybrids, their use in the treatment of inflammatory or cardiovascular diseases and their process of preparation
发明人：MOTTERLINI ROBERTO; FORESTI ROBERTA; MARTENS THIERRY; RIVARD MICHAEL
权利人:UNIV PARIS VAL DE MARNE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED
摘要:The present invention relates to hybrid fumarate-CO-releasing molecules capable of increasing heme oxygenase-1 (HO-1) activity and HO-1 protein expression and simultaneously releasing CO, their synthesis and their use in therapeutic applications, in particular their use in the treatment of inflammatory or cardiovascular diseases.

专利号:JP-6241682-B2
优先权日:2012-04-27
标题:Process for the synthesis of activated ethyl fumarate and its use as an intermediate

专利号:JP-2015519321-A
优先权日:2012-04-27
标题 :Process for the synthesis of activated ethyl fumarate and its use as an intermediate

专利号:WO-2013162764-A1
优先权日:2012-04-27
标题:Methods for the synthesis of ethylfumarates and their use as intermediates

专利号:AU-2018201397-B2
优先权日:2012-04-27
标题 :Methods for the synthesis of ethylfumarates and their use as intermediates