CAS: 289-80-5; Pyridazine

该化合物是环状有机化合物,其特点是六人环,内含两个相邻氮原子.其分子分子式为C4H4N2,被归类为二氮,是一种芳香化合物.由于环状电子迁移而形成一个平板结构,有助于其稳定性和芳香性.根据形式和纯度,该化合物一般没有色素,可变成黄色液体或固体.以其再活动性为名,特别是在电子生物替代反应中,可以作为各种药物和农用化学合成的建筑块.它有一个中度沸点,在极地溶剂中溶解.此外,衍生物可以展示多种生物活动,使其对药用化学具有兴趣.在处理时,应当采取安全防范措施,因为它在接触时可能会对健康造成危害.

结构式图片

相似化合物

6164-80-3 53896-49-4 4603-59-2

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ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    4,4-Diethoxy-3-Hydroxybutanal置于硫酸肼体系中,用 甲醇,水 用作溶剂,化学反应 18.0H,以80%的收率获得哒嗪
    参考文献:New Routes To γ-Ketoesters,β-Hydroxy-δ-Ketoesters,α,β-Unsaturated γ-Ketoaldehydes,And Acetals. Synthesis Of Cyclopentenones
    标题:New Routes To γ-Ketoesters,β-Hydroxy-δ-Ketoesters,α,β-Unsaturated γ-Ketoaldehydes,And Acetals. Synthesis Of Cyclopentenones
    摘要:
    Doi:10.1016/s0040-4020(01)91249-9

    专利信息


    专利号:US-9126995-B2
    优先权日:2011-11-08
    标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
    发明人:TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
    权利人:NISSAN CHEMICAL IND LTD
    摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

    专利号:US-8309740-B2
    优先权日:2008-05-13
    标题 :One-pot synthesis of fluorinated ionic liquids
    发明人:LEE HYUN JOO; SUH DONG JIN; AHN BYOUNG SUNG; KIM HONG GON; KIM CHANG SOO; KIM HOON SIK
    权利人:LEE HYUN JOO; SUH DONG JIN; AHN BYOUNG SUNG; KIM HONG GON; KIM CHANG SOO; KIM HOON SIK; KOREA INST SCI & TECH
    摘要:The present invention relates to a method for one-pot synthesis of ionic liquid with fluoroalkyl group, more particularly to a method for one-pot synthesis of ionic liquid with fluoroalkyl group represented by the following Chemical Formula 1 by adding and reacting a nitrogen-containing compound, a Brønsted acid of the formula YH and a fluoroolefin compound of the formula CFR 1 â•?CR 2 R 3 in a single reactor: n n n n n n n n n n wherein n nrepresents a nitrogen-containing compound; Y − represents an anion of the Brønsted acid; and R 1 , R 2 and R 3 , which may be same or different, represent hydrogen, fluorine, C 1 -C 10 alkyl or C 1 -C 10 fluoroalkyl having from 1 to 23 fluorine atoms.

    专利号:US-5569762-A
    优先权日:1994-01-14
    标题:Asymmetric synthesis of intermediates for retroviral protease inhibitor compounds
    发明人:WISSNER ALLAN; TROVA MICHAEL P
    权利人:AMERICAN CYANAMID CO
    摘要:The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R 1 , R 50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.

    专利号:WO-2024201393-A1
    优先权日:2023-03-29
    标 题:Methods for the synthesis of nucleoside analogues and nucleosides analogues derived therefrom
    发明人:BRITTON ROBERT; Muir Garrett; ANKETELL MATTHEW JAMES; HUXLEY COHAN; BAIKABI SUPING
    权利人:UNIV FRASER SIMON
    摘要:The present invention relates to methods for the synthesis of nucleoside analogues. More specifically, the present invention relates to methods for the synthesis of C4' substituted nucleoside analogues via the reaction of a soft nucleophile with a halohydrin ketone.

    专利号:US-2006128930-A1
    优先权日:2004-12-03
    标题 :Synthesis of sterically hindered phenol based macromolecular antioxidants
    发明人:DHAWAN ASHISH; CHOLLI ASHOK L
    权利人:DHAWAN ASHISH; CHOLLI ASHOK L
    摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes polymerizing and alkylating a phenol containing monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.

    专利号:US-7678877-B2
    优先权日:2004-12-03
    标题 :Process for the synthesis of polyalkylphenol antioxidants
    发明人:YANG SUIZHOU; CHOLLI ASHOK L
    权利人:POLNOX CORP
    摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes partially etherifying, polymerizing and thermally rearranging a phenol containing monomer represented by the following structural formula: n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
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    合成参考文献


    参考文献:10.2478/v10102-011-0013-y
    摘要:Stefek M. Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract. Interdiscip Toxicol. 2011 Jun;4(2):69–77.
    参考文献:10.1107/s1600536811008634
    摘要:Starosta W, Leciejewicz J. Poly[aqua(μ3-pyridazine-4-carboxylato-κ2O:O:O′)lithium]. Acta Crystallogr E Struct Rep Online. 2011 Mar 12;67(4):m425–6. doi: 10.1107/s1600536811008634.
    参考文献:10.1107/s1600536811011342
    摘要:Ather AQ, Tahir MN, Khan MA, Athar MM. 3-Chloro-6-[2-(cyclo-pentyl-idene)hydrazin-1-yl]pyridazine. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o1020.
    参考文献:10.1107/s1600536811012621
    摘要:Reinert T, Boeckmann J, Näther C. Bis(pyridazine-κN)bis(selenocyanato-κN)zinc. Acta Crystallogr E Struct Rep Online. 2011 Apr 13;67(5):m567. doi: 10.1107/s1600536811012621.
    参考文献:10.1107/s1600536811011597
    摘要:Ju ZY, Jiang WX, Yang FL. 2-Benzyl-6-benz-yloxypyridazin-3(2H)-one. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1042.
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