在 正丁基锂体系中,用 乙醚 作为反应溶剂,化学反应生成 异丙基缩水甘油醚 参考文献:Complexes Of Cyclic Polyaza Chelators With Cations Of Alkaline Earth Metals For Enhanced Biological Activity 标题:Complexes Of Cyclic Polyaza Chelators With Cations Of Alkaline Earth Metals For Enhanced Biological Activity 摘要:具有高亲和力和特异性的环状多氮螯合剂,当与碱土金属阳离子的络合物一起给药时,表现出生物活性的意外改善,其中以ca(II)和mg(II)的络合物最为显著,尤其是ca(II).由于这种改善,这些络合物在治疗病理条件,包括缺血和缺血再灌注损伤方面特别有效.
专利号:US-8541571-B2 优先权日:2008-03-03 标题:Homogeneous synthesis of cellulose ethers in ionic liquids 发明人:MOELLMANN EUGEN; HEINZE THOMAS; LIEBERT TIM; KOEHLER SARAH 权利人:MOELLMANN EUGEN; HEINZE THOMAS; LIEBERT TIM; KOEHLER SARAH; SE TYLOSE GMBH & CO KG 摘要:The invention is directed to a simple and new method for the homogeneous synthesis of cellulose ethers. Ionic liquids are not only used as solvent, but also as reaction media for the homogeneous etherification of cellulose. The dissolved cellulose is treated with the etherification agent in the absence of organic and/or inorganic bases and in the absence and/or in the presence of moderate amounts of water. The obtained cellulose ethers show new distributions of substitution on the polymer chain, resulting in new properties and applications.
专利号:US-7038062-B2 优先权日:2004-07-01 标题:Synthesis of cyclic trithiocarbonates from epoxides 发明人:PARKER DANE KENTON 权利人:GOODYEAR TIRE & RUBBER 摘要:This invention provides a low cost technique for synthesizing cyclic trithiocarbonates by a simple one step process from epoxides that can be conducted under atmospheric pressure. This synthesis can be depicted as follows: n nwherein R represents a moiety selected from the group consisting of alkyl groups and aryl groups, wherein R′ represents a moiety selected from the group consisting of alkyl groups, aryl groups, and hydrogen atoms, and wherein R″ represents a moiety selected from the group consisting of alkyl groups, aryl groups, and hydrogen atoms, wherein the R moiety and the R′ moiety can be bonded together to form a cyclic structure, with the proviso that R″ represents a hydrogen atom if R′ represents an alkyl group or an aryl group. In this process carbon disulfide and a thiocyanate salt, such as potassium thiocyanate, are reacted with the epoxide in an ionic liquid, such as 1-butyl-3-methylimidazolium hexafluorophosphate ([Bmim] PF 6 ) in the presence of water to produce the cyclic trithiocarbonate.
专利号:WO-9967219-A1 优先权日:1998-06-22 标 题:Compounds for inhibiting beta-amyloid peptide release and/or its synthesis 发明人:AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING 权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING 摘要:Compounds of formula (I), wherein W is a cyclic group of the type (2); (3); Y is represented by the formula (II); these compounds inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-6838455-B2 优先权日:1998-06-22 标题 :Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds 发明人:AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING 权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-10316134-B2 优先权日:2014-09-09 标题:Alkenyl ether polyols 发明人:TADEN ANDREAS; LANDFESTER KATHARINA; KIRSCHBAUM STEFAN 权利人:HENKEL AG & CO KGAA; MAX PLANCK GESELLSCHAFT 摘要:The invention relates to a method for producing radiation-curable alkenyl ether polyols, to radiation-curable alkenyl ether polyols produced using the method according to the invention, and to the use thereof for the synthesis of radiation-interlinkable oligomers or polymers by means of polyaddition reactions or polycondensation reactions, in particular for the synthesis of radiation-curable polyesters, polyethers, polyurethanes and polyureas, particularly preferably UV-curable polyurethanes. The invention also relates to radiation-curable polyurethane polymers that are obtained by reacting at least one alkenyl ether polyol according to the invention with a polyisocyanate.
专利号:US-2008051323-A1 优先权日:2004-08-21 标 题 :Chloroquine drug compositions and methods for their synthesis 发明人:KOSAK KENNETH M 权利人:KOSAK KENNETH M 摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. n The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.
[参考文献]: P Foureman, Et Al. Chemical Mutagenesis Testing In Drosophila. Ix. Results Of 50 Coded Compounds Tested For The National Toxicology Program. Environ Mol Mutagen. 1994;23(1):51-63. [参考文献]: R Zeeman, Et Al. The Kinetics Of 1,4-Butanediol Diglycidyl Ether Crosslinking Of Dermal Sheep Collagen. J Biomed Mater Res. 2000 Sep 15;51(4):541-8. [参考文献]: Takashi Toyao, Et Al. Design Of Zeolitic Imidazolate Framework Derived Nitrogen-Doped Nanoporous Carbons Containing Metal Species For Carbon Dioxide Fixation Reactions. Chemsuschem. 2015 Nov;8(22):3905-12.
合成参考文献
摘要:Braverman, S.; Cherkinsky, M., Science of Synthesis Knowledge Updates, (2014) 3, 276. 摘要:Aitken, R. A., Science of Synthesis Knowledge Updates, (2018) 3, 317. 摘要:Vilhelmsen, M. H., Science of Synthesis Knowledge Updates, (2014) 2, 362. 摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2019) 1, 352. 摘要:Johnson, J. B., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 781.