CAS: 586-37-8; 3'-Methoxyacetophenone

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CAS号768-70-7 3-乙炔基苯甲醚 | CAS号121-71-1 3-羟基苯乙酮 | CAS号77-78-1 硫酸二甲酯 | CAS号498-02-2 香草乙酮 | CAS号2398-37-0 间溴苯甲醚 | CAS号111-34-2 乙烯基正丁醚 | CAS号5000-65-7 3'-甲氧基苯乙酰溴[用于高效... | CAS号766-85-8 3-碘苯甲醚 | CAS号108-24-7 乙酸酐 | CAS号110718-87-1 1-(2-iodo-5-met... | CAS号107027-41-8 2-(3-甲氧基苯基)-8-甲... | CAS号5000-65-7 3'-甲氧基苯乙酰溴[用于高效... | CAS号32025-65-3 3-甲氧基苯基乙二醛水合物 | CAS号42465-54-3 1-(2-氨基-3-甲氧基-苯基)-乙酮 | CAS号23042-77-5 1-(2-氨基-5-甲氧基苯基)-乙酮 | CAS号5020-41-7 2-(3-甲氧基苯基)乙醇 | CAS号37951-49-8 间甲氧基苯丙酮 | CAS号18463-71-3 2-(3-甲氧基苯基)乙酰胺 | CAS号189289-49-4 N-[3-(2-chlorop...

3-乙炔基苯甲醚置于水体系中,化学反应 15.0H,以97%的收率获得产物3-甲氧基苯乙酮
参考文献:在末端炔烃直接水合中具有高活性的沸石y纳米粒子组件†
标题:在末端炔烃直接水合中具有高活性的沸石y纳米粒子组件†
摘要:合成了具有微中观大分子结构的强酸性沸石y纳米粒子组件(hnano-Y),与酸性介孔沸石zsm-5和beta催化剂.该特征应归因于以下事实:Hnano-Y中的微-中-大结构有利于质量转移,Hnano-Y上的强酸性部位促进炔烃的水合活性.催化剂可以重复使用六次而不会失去活性.
DOI:10.1039/c6Ra11489J

专利信息

专利号:US-8791287-B2
优先权日:2010-07-02
标 题:Process for the synthesis of tapentadol and intermediates thereof
发明人：MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO; LANDONI NICOLA
权利人:MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO; LANDONI NICOLA; EUTICALS SPA
摘要:The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Diagram 1, with high stereoselectivity due to the presence of the benzyl group as substituent of the amino group. It was surprisingly found that this substitution shifts the keto-enol equilibrium towards the desired enantiomer and amplifies the capacity of the stereocenter present in the compound (VII) to orient the nucleophilic addition of the organometallic compound at the carbonyl towards the desired stereoisomer. This substitution thus allows obtaining a considerable increase of the yields in this step, and consequently allows significantly increasing the overall yield of the entire tapentadol synthesis process. n A further object of the present invention is constituted by the tapentadol free base in solid form, obtainable by means of the process of the invention. n Still another object of the invention is represented by the crystalline forms I and II of the tapentadol free base. n A further object of the present invention is the mixture of the crystalline forms I and II of the tapentadol free base.

专利号:US-2004101523-A1
优先权日:1989-07-27
标题:Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension
发明人：REITZ DAVID B; KOEPKE JOHN P; BLAINE EDWARD H; SCHUH JOSEPH R; MANNING ROBERT E; SMITS GLENN J
权利人:SEARLE & CO
摘要:Renal-selective prodrugs are described which are preferentially converted in the kidney to compounds capable of inhibiting synthesis of catecholamine-type neurotransmitters involved in renal sympathetic nerve activity. The prodrugs described herein are derived from inhibitor compounds capable of inhibiting one or more of the enzymes involved in catecholamine synthesis, such compounds being classifiable as tyrosine hydroxylase inhibitors, or as dopa-decarboxylase inhibitors, or as dopamine-β-hydroxylase inhibitors. These inhibitor compounds are linked to a chemical moiety, such as a glutamic acid derivative, by a cleavable bond which is recognized selectively by enzymes located predominantly in the kidney. The liberated inhibitor compound is then available in the kidney to inhibit one or more of the enzymes involved in catecholamine synthesis. Inhibition of renal catecholamine synthesis can suppress heightened renal nerve activity associated with sodium-retention related disorders such as hypertension. Conjugates of particular interest are glutamyl derivatives of dopamine-β-hydroxylase inhibitors, of which N-acetyl-γ-glutamyl fusaric acid hydrazide (shown below) is preferred.

专利号:US-7176230-B2
优先权日:2004-11-16
标题 :Synthesis of indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl) indazole (YC-1) as anti-platelet agents
发明人：KUO SHENG-CHU; LEE FANG-YU; HUANG TSANG-MIAO; TENG CHE-MING; LEE ON; WU CHIN-YI; HWANG CHRONG-SHIONG; HUNG CHI-YING
权利人:YUNG SHIN PHARM IND CO LTD
摘要:The present invention synthesizes a series of novel indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole (YC-1), and their anti-platelet activity.

专利号:US-11642335-B2
优先权日:2019-09-26
标题 :Chemical synthesis of clopidogrel active metabolites and disulfide conjugate prodrugs
发明人：ZHU YAOQIU
权利人:UNIV TEXAS
摘要:A method of synthesizing a clopidogrel metabolite is provided. A piperidone intermediate is formed from a mandelate. An asymmetric ketone reduction of the piperidone intermediate is performed. A mercapto installation is performed on the piperidone intermediate to form a clopidogrel metabolite that includes a 4-carbon chiral center having an (R) configuration.

专利号:US-2022145179-A1
优先权日:2020-11-12
标题 :Synthesis of aryl 1-(methoxymethyl) vinyl ketones and their use as inhibitors of mild steel corrosion
发明人：MAZUMDER MOHAMMAD ABU JAFAR; ALI SHAIKH ASROF; ODEWUNMI NURUDEEN; ALHARBI BADER; ALJEABAN NORAH; CHEN TAO; BALHARTH SALEM
权利人:SAUDI ARABIAN OIL CO; UNIV KING FAHD PET & MINERALS
摘要:Methods for preparing alkenylphenone corrosion inhibiting compositions may include providing an arylacetone and reacting the arylacetone with formaldehyde in the presence of a strong base catalyst. Corrosion inhibiting compositions may include an alkenylphenone, which may be prepared by a method including providing an arylacetone and reacting the arylacetone with formaldehyde in the presence of a strong base catalyst. Methods of inhibiting corrosion of a steel surface of an oilfield equipment component may include contacting the steel surface with an aqueous solution comprising a corrosion inhibitor. The corrosion inhibitor may include a composition containing an alkenylphenone prepared by reacting an arylacetone with formaldehyde in the presence of a strong base catalyst.

专利号:US-8932838-B2
优先权日:2010-06-17
标 题 :Biocatalysts and methods for the synthesis of (S)-3-(1-aminoethyl)-phenol
发明人：CABIROL FABIEN LOUIS; GOHEL ANUPAM; OH SEONG HO; SMITH DEREK J; WONG BRIAN; LALONDE JAMES J
权利人:CODEXIS INC
摘要:The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3′-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.