对溴三氟甲氧基苯置于bis(Triphenylphosphine)Palladium(II) Dichloride Sodium Formate体系中,用 Co,N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 对三氟甲氧基苯甲醛 参考文献:Process For Preparing Benzyl Alcohols And Their Use 标题:Process For Preparing Benzyl Alcohols And Their Use 摘要:苯甲醇,特别是那些在苯甲基环上带有氟代取代基或氟代烷基取代基的苯甲醇,可以通过对应的芳基溴化物进行甲酰化,形成苯甲醛,再使用进一步的甲酸酯还原苯甲醛来获得.所形成的苯甲醛不需要被分离.
专利号:US-2011263540-A1 优先权日:2008-07-25 标题 :Small-molecule inhibitors of protein synthesis inactivating toxins 发明人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B 权利人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B 摘要:Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are methods of identifying small-molecule inhibitors of a protein synthesis inhibiting toxin.
专利号:US-2022064167-A1 优先权日:2018-05-17 标 题 :Imidazo-pyrazole carboxamide derivatives as anticancer agents and the synthesis thereof 发明人:DEMJÉN ANDRÃ?S; Puskás László; KANIZSAI IVAN; SZEBENI GÃ?BOR; ANGYAL ANIKÓ; GYURIS Márió; Hackler László 权利人:AVIDIN KFT 摘要:The present invention relates to novel imidazo[1,2-b]pyrazole carboxamide and carbothioamide derivatives of general formula (V), and the advantageous derivatives and pharmaceutically acceptable salts thereof, the synthesis thereof, and medicinal and/or pharmaceutical composition comprising these compounds thereof and synthesis thereof, and for use as a medicament, for use in the treatment of different diseases, advantageously of cancer. The subject compounds are advantageously for use in the treatment of solid malignancies, advantageously breast, lung, melanoma, gliomas, and myeloproliferative and myelodysplastic neoplasms, acute myelogenous/myeloid leukemias and colon cancer by the differentiation and subsequent apoptosis of pre-matured myeloid leukemic cells or myeloid-derived suppressor cells and/or by direct effect on solid tumors.
专利号:EP-3515880-B1 优先权日:2017-03-17 标题:Methods and compositions for synthesis of encoded libraries 发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN 权利人:HITGEN INC
专利号:WO-0053313-A2 优先权日:1999-03-09 标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries
专利号:US-2020149034-A1 优先权日:2017-03-17 标题:Methods and Compositions for Synthesis of Encoded Libraries
专利号:US-8318938-B2 优先权日:2006-02-21 标 题:Trans-fused chromenoisoquinolines synthesis and methods for use 发明人:NICHOLS DAVID; WATTS VAL J 权利人:NICHOLS DAVID; WATTS VAL J; PURDUE RESEARCH FOUNDATION 摘要:Optionally substituted chromenoisoquinolines and analogs and derivatives thereof are described herein. In addition, syntheses of these compounds are described herein. In addition, uses of these compounds as dopamine receptor binding compounds are described herein.
[参考文献]: Andreas J Kesel, Et Al. Broad-Spectrum Antiviral Activity Including Human Immunodeficiency And Hepatitis C Viruses Mediated By A Novel Retinoid Thiosemicarbazone Derivative. Eur J Med Chem. 2011 May;46(5):1656-64. [参考文献]: Hooshang Hamidian, Et Al. Synthesis Of Novel Azo Compounds Containing 5(4H)-Oxazolone Ring As Potent Tyrosinase Inhibitors. Bioorg Med Chem. 2013 Apr 1;21(7):2088-92. [参考文献]: Nikhath Fathima, Et Al. 2-[4-(Trifluoro-Meth-Oxy)Phen-Yl]-1H-Benzimidazole. Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 1;69(Pt 2):O264.
合成参考文献
摘要:Song, A.; Wang, W., Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (2015) 2, 389. 摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198 摘要:Yerien, D. E.; Barata-Vallejo, S.; Postigo, A., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 9.