CAS: 75647-01-7; Boc-D-Asn-Oh

相似化合物

108321-39-7 132388-59-1 132388-68-2

上下游产品

N-butyloxycarbonyl-D-asparagine p-nitrophenyl ester (R)-Asparagine tert-butyl dicarbonatedi-tert-butyl dicarbonate(R)-2-tert-butoxycarbonyl-3-aminopropionic acid N-t-butyloxycarbonyl-D-asparagine, benzhydrylester N-butyloxycarbonyl-D-asparagine p-nitrophenyl ester benzyl (2R)-4-amino-2-(tert-butoxycarbonylamino)-4-oxo-butanoate

N-叔丁氧羰基-D-天冬氨酸对硝基苯酯置于ac-Ihihiqi-Nh2,Zinc(II) Chloride体系中,用 Aq. Buffer 作为反应溶剂,化学反应 24.0H,反应生成 Boc-D-天冬酰胺
参考文献:主动组装淀粉样蛋白催化剂的底物特异性
标题:主动组装淀粉样蛋白催化剂的底物特异性
摘要:在 Zn2+ 存在下,发现催化性淀粉样蛋白形成肽 Ac-Ihihiqi-Nh2 在自组装过程中对疏水性对硝基苯酯底物表现出增强的选择性.与底物对硝基苯乙酸盐相反,后者在完全原纤维状态下被 Ac-Ihihiqi-Nh2 更有效地水解,疏水底物 Z-L-Phe-Onp 以大于 11-的二级速率常数转化当催化剂积极组装时,它会增加数倍.在这种条件下,Z-L-Phe-Onp 的水解速度比亲水性更强且更不稳定的 Boc-L-Asn-Onp 酯的水解速度更快.组装时,催化剂对 Z-Phe-Onp 的 L-对映体也表现出更高的选择性.
DOI:10.1002/bip.23003

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2019031650-A1
优先权日:2016-01-29
标 题 :Dna alkylation and cross-linking agents as compounds and payloads for targeted therapies
发明人：HERZON SETH; HEALY ALAN; CRAWFORD JASON; VIZCAINO MARIA; NIKOLAYEVSKIY HERMAN
权利人:UNIV YALE
摘要:The present invention is directed to compounds related to precolibactin pharmaceutical compositions based upon these compounds and methods of synthesis which are employed to provide intermediates and final compounds, which are principally alkylating agents and anticancer compounds. The chemical synthetic approach disclosed facilitates the synthesis of numerous precolibactin analogs which can be used in the treatment of cancer.

专利号:EP-1107981-B1
优先权日:1998-08-20
标题 :Synthesis of ring-modified cyclic peptide analogs

专利号:ES-2233070-T3
优先权日:1998-08-20
标题:SYNTHESIS OF CYCLED PEPTIDIC ANALOGS MODIFIED IN THE RING.