CAS: 81927-55-1; Benzyl 2,2,2-Trichloroacetimidate

上下游产品

trichloroacetonitrile benzyl alcoholtribenzylphosphate benzyl 2,2,2-trichloroacetamide (2R,5S)-3-Benzyloxy-5,6-dihydro-5-(3-hydroxypropyl)-2-methyl-2H-1,4-oxazin (2R,5S)-5-(3-Benzyloxypropyl)-2-methyl-3-morpholinon

三氯乙腈,苯甲醇置于sodium Hydride体系中,用 乙醚,Mineral Oil 作为反应溶剂,化学反应 3.17H,反应生成 2,2,2-三氯乙酰胺苄酯
参考文献:Discodermolide的全合成:有效合成途径的优化.
标题:Discodermolide的全合成:有效合成途径的优化.
摘要:一种高效,可调节的二甲蝶呤(ddm)的合成方法,一种独特的海洋抗癌聚酮化合物,包括相关的替代合成方法.尤其值得注意的是,重复进行crotyltitanate反应,以具有优异的选择性产生均烯丙基(z)-O-烯-氨基甲酸酯醇.利用该反应不仅用于ddm的顺-反甲基-羟基-甲基三单元组的立体控制结构,而且还用于末端(z)-二烯的直接结构.还特别感兴趣的是通过高度选择性的致各向异性重排来安装c13 = C14(z)-双键.在两个连续阶段中制备中间c8-C14片段并将其与c1-C7部分偶联是一个真正的挑战,需要仔细优化.探索了几种合成路线以允许高和可靠的产量.由于这种方法的灵活性和鲁棒性,它可以实现ddm的系统结构变化,因此可以开发和探索新颖的discodermolide结构类似物.
DOI:10.1002/chem.200801478

专利信息

专利号:US-7160517-B2
优先权日:2000-08-18
标题 :Apparatus and methods for the automated synthesis of oligosaccharides
发明人：SEEBERGER PETER H; PLANTE OBADIAH J
权利人:MASSACHUSETTS INST OF TECHNOLG
摘要:One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the present invention is used in combinatorial methods, e.g., as described herein, of synthesizing oligosaccharides.

专利号:US-2022395800-A1
优先权日:2019-11-04
标题:Device for automated synthesis of oligo- and polysaccharides
发明人：SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO
权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A
摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

专利号:US-7102023-B2
优先权日:1999-11-24
标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
发明人：BUCHWALD STEPHEN L; PLANTE OBADIAH J; SEEBERGER PETER H
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.

专利号:EP-3835306-A1
优先权日:2019-12-13
标题:Microwave-assisted method for synthesis of oligo- and polysaccharides on solid phase
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a method for synthesizing oligo- and polysaccharides using microwave radiation, in particular to a method and a device for automated synthesis of oligo- and polysaccharides.

专利号:US-2014336369-A1
优先权日:2011-06-28
标题:Process for preparing heparinoids and intermediates useful in the synthesis thereof
发明人：KOVI RAVISHANKER; NAIK ASHISH; PATEL BRIJESH; MADALA MURALIKRISHNA
权利人:APICORE US LLC
摘要:Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.

专利号:US-9403841-B2
优先权日:2012-01-25
标题:Phragamalin limonoids for the treatment of sexual dysfunction
发明人：WIKBERG JARL; JIRGENSONS AIGARS; LIEPINSH EDVARDS
权利人:DICOTYLEDON AB
摘要:The present invention relates to novel chemical compounds, to methods for synthesis of such compounds, and to the use of these novel compounds in the synthesis of other chemical compounds that, inter alia, may be used in the treatment of sexual dysfunction, and for eliciting enhancing effects on sexual behavior. The invention also relates to remarkable biological properties of the novel compounds in their capacity of inducing aggressive behavior.