CAS: 873054-44-5; N-(2,4-Di-Tert-Butyl-5-Hydroxyphenyl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxamide

上下游产品

5-amino-2-4-di-tert-butyl-phenol 2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate 3-methyl-4-nitro-1H-indole 5-amino-2,4-di-tert-butylphenyl methyl carbonateN-(2-(tert-butyl)-5-hydroxy-4-(1-hydroxy-2-methylpropan-2-yl)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide 2-(5-tert-butyl-2-hydroxy-4-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl)-2-methylpropanoic acid N-(5-hydroxy-2,4-ditert-butyl-phenyl)-5-methyl-4-oxo-1H-quinoline-3-carboxamide N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide.besylate

4-Chloro-N-(2,4-Ditert-Butyl-5-Hydroxyphenyl)Quinoline-3-Carboxamide置于盐酸体系中,用 水,乙腈 作为反应溶剂,化学反应 6.0H,以88%的收率获得产物n-(2,4-二叔丁基-5-羟基苯基)-1,4-二氢-4-氧代-3-喹啉甲酰胺
参考文献:一种ivacaf Tor的合成方法及其中间体
标题:一种ivacaf Tor的合成方法及其中间体
摘要:本发明涉及一种ivacaftor的合成方法及其中间体,通过如下式方法实施,本发明合成路线新颖,操作简便,收率高,安全性好,适合工业化生产.还包括如式7或8所示的新型中间体,其中x为氯或溴,R为氢或c1~c5的烷基,优选为氢,甲基或乙基.

专利信息

专利号:US-11274081-B2
优先权日:2016-05-30
标 题:Process for the synthesis of ivacaftor
发明人：REDDY DUMBALA SRINIVASA; KULKARNI AMOL ARVIND; NATARAJAN VASUDEVAN; SHARMA MRITYUNJAY KESHAVPRASAD
权利人:COUNCIL SCIENT IND RES
摘要:The present disclosed an improved process for the synthesis of ivacaftor starting from indole acetic acid ester which can be performed in batch as well as continuous flow synthesis. The present invention further disclosed to a continuous process for the synthesis of compound of formula (II) or formula (III) from compound of formula (I) in continuous flow reactor.

专利号:US-10336703-B2
优先权日:2015-05-12
标题 :Process for the synthesis of ivacaftor and related compounds
发明人：REDDY DUMBALA SRINIVASA; NATARAJAN VASUDEVAN; JACHAK GORAKHNATH RAJARAM
权利人:COUNCIL SCIENT IND RES
摘要:The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and Ar 1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.

专利号:US-2023002411-A1
优先权日:2019-12-20
标 题:Deuterated analogues of selenophenochromenes, synthesis thereof, and methods of using same agents
发明人：ARSENJANS PAVELS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to a novel cancer curing deuterated selenopheno [h] chromene derivatives, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment of cancer by administration of such substances.

专利号:US-12252473-B2
优先权日:2022-04-18
标 题:Preparation methods of quinolone compounds and intermediates thereof
发明人：LEI JIE; CHEN ZHONGZHU; XU ZHIGANG; TANG DIANYONG; XU JIAYU; ZHOU HAOYI; XIA DANDAN; LIU YAO; CAO YIHUA; LUO JIE
权利人:UNIV CHONGQING ARTS & SCIENCES
摘要:The present application relates to processes for the preparation of quinolone compounds and intermediates thereof, particularly to processes for the preparation of quinolones and pharmaceutical intermediates of the quinolones. In particular, the present application provides a process for the preparation of a compound of Formula I, and a process for the synthesis of quinolone compounds using the compound of Formula I as an intermediate. The process for the preparation of the compound of Formula I comprises the steps of:reacting a compound of Formula A with R5NH2 and R6Cl in the presence of a base to form the compound of Formula I,

专利号:WO-2017208253-A9
优先权日:2016-05-30
标 题:An improved process for the synthesis of ivacaftor

专利号:US-2018127373-A1
优先权日:2015-05-12
标题:Process for the synthesis of ivacaftor and related compounds