CAS: 1192-58-1; 1-Methylpyrrole-2-Carboxaldehyde

相似化合物

161282-57-1 37619-24-2 6973-60-0

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CAS号51485-76-8 (2E)-3-(1-METHY...

N-甲基吡咯置于三氯氧磷体系中,用 N-甲基乙酰胺,Sodium Hydroxide,1,1-二氯乙烷,氯仿 用作溶剂,化学反应生成N-甲基-2-吡咯甲醛
参考文献:Antipsychotic Fused-Ring Pyridinylpiperazine Derivatives
标题:Antipsychotic Fused-Ring Pyridinylpiperazine Derivatives
摘要:披露了二取代的1,4-哌嗪衍生物,其中一个取代基是一个融合环的呋喃,吡咯,环戊二烯或噻吩-吡啶杂环系统,第二个取代基是连接到环状咪唑环的烷基链,例如氮杂螺[4.5]癸烷二酮,二烷基戊二酰亚胺,噻唑烷二酮,琥珀酰亚胺和吗啉-2,6-二酮;或苄基醇基团.这些化合物具有强效的抗精神病和5-羟色胺拮抗活性.4-[4-[4-(4-呋喃[3,2-C]吡啶基)-1-哌嗪基]丁基]-3,5-吗啉二酮是一个具有选择性抗精神病活性的典型实施例.

专利信息

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:WO-2005103035-A1
优先权日:2004-04-23
标题:Modified fischer indole synthesis of eletriptan
发明人：ASHCROFT CHRISTOPHER PAUL
权利人:PFIZER LTD; ASHCROFT CHRISTOPHER PAUL; PFIZER
摘要:The present invention relates to a new process for the preparation of eletriptan (I), or its enantiomer comprising a modified Fischer indole synthesis, namely the reaction of a compound of formula (II), wherein R1 is a suitable hydrazine protecting group, with a compound of formula (III) wherein R2 is an aldehyde group (-CHO) or the functional equivalent thereof.

专利号:US-4567265-A
优先权日:1984-01-16
标题:Cyclopropanoid cyanoesters and method of making same
发明人：BABLER JAMES H
权利人:UNIV LOYOLA CHICAGO
摘要:Cyclopropanoid cyanoesters of the formula: where R' is -CH3 or -CH2CH3, and A is (a) -H, or (b) A, B represents an aliphatic group joined to a carbon atom on the cyclopropanoid ring, thereby forming a spiro group, A, B being selected from structures having the formula: (i) -(CH2)n-, wherein n=3, 4, or 5, and (ii) -(CH2)2-Y-(CH2)2-, wherein Y is NCH3, O, or S); and, when A is -H, B is selected from the group consisting of: +TR (CH3)2CHCH2. are disclosed. These compositions are useful in the synthesis of pyrethroids. A process for synthesis of cyclopropanoid cyanoesters by reacting 2-nitropropane with cyanoesters of the general formula: is also disclosed and claimed.

专利号:US-7067622-B2
优先权日:2001-06-25
标题 :Method of the solid phase synthesis of pyrrole-imidazole polyamide
发明人：SUGIYAMA HIROSHI; IIDA HIROKAZU; SAITO ISAO; SAITO TAKASHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:It is intended to provide a method of producing a pyrrole-imidazole polyamide whereby a longer pyrrole-imidazole polyamide can be conveniently synthesized and a peptide (protein) can be easily transferred. According to this method, a pyrrole-imidazole polyamide having a carboxylate group which can be excised from a solid phase carrier at its end, makes it possible to directly transfer various functional groups and can exactly distinguish DNA sequences can be efficiently produced. A method of synthesizing a pyrrole-imidazole polyamide characterized by performing automatic synthesis by the solid phase Fmoc method with the used of a peptide synthesizer; a pyrrole-imidazole polyamide having a carboxyl group at its end obtained by this method; a pyrrole-imidazole polyamide having a DNA alkylation agent transferred into the carboxyl group at the end of the above-described pyrrole-imidazole polyamide; and a sequence-specific DNA alkylation method characterized by using the above compound.

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:US-5175302-A
优先权日:1987-07-13
标 题 :Nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.