CAS: 1229194-11-9; N1-(5-Chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(Dimethylcarbamoyl)-2-(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine-2-Carboxamido)Cyclohexyl)Oxalamide 4-Methylbenzenesulfonate Hydrate

4,5,6,7-四氢-5-甲基-噻唑并[5,4-C]吡啶 反应生成伊多塞班对甲苯磺酸盐一水化合物
参考文献:Diamine Derivatives
标题:Diamine Derivatives
摘要:一种由通式(1)表示的化合物:Q1-Q2-T0-N(r1)-Q3-N(r2)-T1-Q4 (1)其中r1和r2是氢原子或类似物;Q1是饱和或不饱和的,5-或6-成员环烃基,可以是取代基或类似物;Q2是单键或类似物;Q3是一个基团,其中q5是具有1至8个碳原子的烷基或类似物;T0和t1是羰基基团或类似物;其盐,溶剂化物或n-氧化物.该化合物可用作预防和/或治疗脑梗死,脑栓塞,心肌梗死,心绞痛,肺梗死,肺栓塞,布尔格病,深静脉血栓形成,弥散性血管内凝血综合征,瓣膜或关节置换后的血栓形成,血管成形术后的血栓形成和再闭塞,全身炎症反应综合征(sirs),多器官功能障碍综合征(mods),体外循环期间的血栓形成或采血时的血液凝固.

专利信息

专利号:US-2015239909-A1
优先权日:2012-11-23
标 题 :Process for the preparation of (1s,4s,5s)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one
发明人：NAKAMURA YOSHITAKA; MUKESH Kumar Madhra; INAMDAR MURAD ISMAIL
权利人:DAIICHI SANKYO CO LTD
摘要:The present invention relates to an improved and industrially advantageous process for the preparation of (1S, 4S, 5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one represented by the following formula (1) n n n n n n n n n n which is a key intermediate in the synthesis of edoxaban, a compound that exhibits on inhibitory effect on activated blood coagulation factor X (also referred to as activated factor X or FXa), and is useful as a preventive and/or therapeutic drug for thrombotic diseases. The process includes reacting (1S)-cyclohex-3-ene-1-carboxylic acid of formula (II) with a brominating agent selected from the group consisting of N-bromosuccinimide or 1,3-dibromo-5, 5-dimethylhydantoin in the presence of a base selected from calcium oxide or calcium hydroxide in a solvent selected from the group comprising of dicholoromethane, toluene, tetrahydrofuran, ethyl acetate, hexanes, cyclopentyl methyl ether (CPME) or a misture thereof to get (1S, 4S 5S)-4-bromo-6-oxabicyclo[3.2.1]octan-y-one of formula (1)

专利号:US-9809546-B2
优先权日:2016-03-14
标 题 :Process for producing diamine derivative
发明人：LU TZU-CHIANG; CHEN CHIEN-YI; CHENG CHING-SHUEN; MAI CHIN-CHENG
权利人:CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO LTD; CHUNGWHA CHEMICAL SYNTHESIS & BIOTECH CO LTD
摘要:The present invention provides a low-toxic and high-recovery industrial process for synthesizing an optically active diamine derivative represented by formula (D), the process comprising the steps of: (a) mixing a compound represented by formula (A) and a compound represented by formula (C) in organic solvents and secondary amine; (b) reaction under heating; (c) cooling and adding water to the mixed solution, allowing it to crystallize to obtain the compound represented by formula (D).