CAS: 143254-82-4; 1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride

相似化合物

1026078-50-1 4897-50-1 883546-10-9

4-哌啶基哌啶,三光气置于二氯甲烷,乙腈,甲苯体系中,用 二氯甲烷 用作溶剂,化学反应生成1-氯甲酰基-4-哌啶基哌啶盐酸盐
参考文献:Process For Producing [1,4'] Bipiperdinyl-1'-Carbonyl Chloride Or Hydrochloride Thereof
标题:Process For Producing [1,4'] Bipiperdinyl-1'-Carbonyl Chloride Or Hydrochloride Thereof
摘要:本发明涉及使用氯甲烷作用作溶剂,在4-哌啶基哌啶与光气反应中制备[1,4']双哌嗪基-1'-羰基氯化物或其盐酸盐,并使用额外的蒸馏溶剂去除反应溶剂以提高蒸馏温度的制备过程.

专利信息

专利号:US-9765083-B2
优先权日:2013-12-03
标 题 :Method for the synthesis of irinotecan
发明人：ZABUDKIN ALEXANDER; MATVIENKO VIKTOR
权利人:SYNBIAS PHARMA AG
摘要:The present invention relates to a method for the synthesis of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. iriniotecan), comprising: (a) preparing 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptotecin; and (b) selectively ethylating the compound of step (a) at the 7-position, thus resulting in the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin. The present invention is further directed to the use of 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. 7-des-ethyl-irinotecan) as intermediate in a method for the synthesis of irinotecan as described.

专利号:WO-2012032531-A1
优先权日:2010-09-06
标 题:Process for the manufacture of irinotecan hydrochloride by total synthesis
发明人：ALLA VENKATA RAMA RAO; RAO RAMAKRISHNA; RAMARAO CHANDRASHEKAR; NANDIPATI RAMADEVI; CHAMLE VINAY AVINASH
权利人:AVRA LAB PVT LTD; ALLA VENKATA RAMA RAO; RAO RAMAKRISHNA; RAMARAO CHANDRASHEKAR; NANDIPATI RAMADEVI; CHAMLE VINAY AVINASH
摘要:Disclosed herein is a highly safe and easily scalable process for the production of 7-Ethyl- 10-hydroxycamptothecin and its conversion to Irinotecan hydrochloride by total synthesis.

专利号:EP-3030567-A1
优先权日:2013-12-03
标题 :Method for the synthesis of irinotecan

专利号:EP-3030567-B1
优先权日:2013-12-03
标题 :Method for the synthesis of irinotecan

专利号:US-2016264590-A1
优先权日:2013-12-03
标题 :Method for the synthesis of irinotecan

专利号:AU-2014359552-B2
优先权日:2013-12-03
标题 :Method for the synthesis of irinotecan