CAS: 18642-44-9; (1R,2R,2A'R,4S,4'S,5S,6A'R,7A'R,9'R,9A'R,9B'R,10'R,13A'S,14A'S,14B'S)-4-Hydroxy-3',3',5,9A',10',14A'-Hexamethyl-4'-(((2S,3R,4S,5R)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-yl)Oxy)Hexadecahydro-1'H,7'H-3,6-Dioxaspiro[bicyclo[3.1.0]Hexane-2,12'-Cyclopropa[1',8A']Naphtho[2',1':4,5]Indeno[2,1-B]Pyran]-9'-Yl Acetate

上下游产品

cimicifugoside

Cimicifugoside置于palladium On Activated Charcoal 氢气体系中,用 乙醇 用作溶剂,化学反应 24.0H,反应生成黄肉楠碱
参考文献:Studies On The Constituents Of Cimicifuga Species. Xx. Absolute Stereostructures Of Cimicifugoside And Actein From Cimicifu Simplex Wormsk.
标题:Studies On The Constituents Of Cimicifuga Species. Xx. Absolute Stereostructures Of Cimicifugoside And Actein From Cimicifu Simplex Wormsk.
摘要:通过对由 1 制备的 26(S)-O-甲基升麻素 A (1Cs)的 X 射线晶体分析,26-O-甲基-3-酮基升麻素 (1Ds,1Dr)的负 Cd 曲线,1,2 及其衍生物的 1H 和 13C-NMR 光谱的比较分析,以及通过氢化由 1 制备 2,确定了来自单叶升麻的升麻苷 (1) 和升麻素 (2)的绝对立体结构:20(R),23(R),24(R),25(S),26(R,S)-16β : 23; 23 : 26; 24 : 25-三环氧-12β-乙酰氧基-3β,26-二羟基-9,19-环羊毛甾-7-烯 3-O-β-D-吡喃木糖苷为 1,20(R),23(R),24(R),25(S),26(R,S)-16β :23;23:26;24:25-三环氧-12β-乙酰氧基-3β,26-二羟基-9,19-环羊毛甾烷 3-O-β-D-吡喃木糖苷为 2.
Doi:10.1248/cpb.46.467

专利信息

专利号:US-8263755-B2
优先权日:2006-11-20
标题:Synthesis of compounds useful as modulators of amyloid-beta production
发明人：FINDEIS MARK A
权利人:FINDEIS MARK A; SATORI PHARMACEUTICALS INC
摘要:As described herein, the present invention provides methods for preparing compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.

专利号:US-2010197615-A1
优先权日:2006-11-20
标题:Synthesis of compounds useful as modulators of amyloid-beta production