专利号:US-4894456-A 优先权日:1987-03-31 标题 :Synthesis of camptothecin and analogs thereof 发明人:WALL MONROE E; WANI MANSUKH C; NICHOLAS ALLAN W; MANIKUMAR GOVINDARAJAN 权利人:RES TRIANGLE INST 摘要:A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.
专利号:US-11040977-B2 优先权日:2013-12-05 标题 :Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[e]azulene and crytalline forms thereof 发明人:ROTHENHAEUSLER BENNO; TRUSSARDI RENE; HOFFMANN-EMERY FABIENNE; SCHWITTER URS; ADAM JEAN-MICHEL; GRASSMANN OLAF; HARTUNG THOMAS; RAN FREDERIC; DIODONE RALPH; PFLEGER CHRISTOPHE; BARTELS BJORN 权利人:HOFFMANN LA ROCHE 摘要:The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
专利号:US-4981968-A 优先权日:1987-03-31 标题:Synthesis of camptothecin and analogs thereof 发明人:WALL MONROE E; WANI MANSUKH C; NICHOLAS ALLAN W; MANIKUMAR GOVINDARAJAN 权利人:RES TRIANGLE INST 摘要:A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.
专利号:US-2023295613-A1 优先权日:2020-02-14 标 题:Long chain carbon and cyclic amino acids substrates for genetic code reprogramming 发明人:JEWETT MICHAEL C; LEE JOONGOO; MOORE JEFFREY S; SCHWARZ KEVIN J 权利人:UNIV NORTHWESTERN; UNIV ILLINOIS 摘要:Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.
专利号:US-2024002405-A1 优先权日:2022-06-01 标题 :Antimicrobial compounds, synthesis methods, and uses thereof 发明人:VERMA RAJNI; DONAVALLI KRISHNA MOHAN; ZAID GENE H 权利人:ANKH LIFE SCIENCES LTD 摘要:Fused tricyclic compounds and novel methods of synthesizing, using, and/or administering the same. Methods of inhibiting microbial activity and/or treating a microbial infection with fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds. The treatment of subjects suffering from a microbial infection comprises the step of administering to the subject one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds or a composition comprising one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds.
专利号:US-2019194210-A1 优先权日:2013-12-05 标 题 :Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crytalline forms thereof
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 234. 摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 393. 摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 192. 摘要:Lou, S.; Zhang, J., Science of Synthesis Knowledge Updates, (2012) 2, 257. 摘要:Kang, F.-A.; Yang, S.-M., Science of Synthesis Knowledge Updates, (2015) 2, 195.