CAS: 26153-38-8; 3,5-Dihydroxybenzaldehyde

上下游产品

3,5-dihydroxystilbene 3,5-diacetoxybenzoyl chloride 3,5-bis-methoxycarbonyloxy-benzaldehyde 4'-methoxy-stilbene-3,5,3'-triol 2,3,5‐trihydroxybenzaldehyde 3,5-diacetoxybenzaldehyde 3-benzyloxy-5-hydroxybenzaldehyde AG 83

3,5-二甲氧基苯甲醛置于aluminum (III) Chloride体系中,用 二氯甲烷 用作溶剂,化学反应生成3,5-二羟基苯甲醛
参考文献:一种含有白藜芦醇的抑制耐药金葡菌的药物组合物
标题:一种含有白藜芦醇的抑制耐药金葡菌的药物组合物
摘要:本发明属于药学领域,涉及化合物3,4',5‑三羟基二苯乙烯(白藜芦醇resveratrol)及其在制备抗耐氟喹诺酮类耐甲氧西林金黄色葡萄球菌增敏药物中的用途.所述的化合物3,4',5‑三羟基二苯乙烯(Resveratrol)分布广泛,目前至少已在21个科,31个属,72种植物中发现白藜芦醇resveratrol,其中在葡萄,虎杖和花生中含量较高,且没有明显的毒副作用.本发明的化合物经抗菌实验显示具有提高多药耐药金黄色葡萄球菌对诺氟沙星的敏感性的药理活性,尤其是针对含有耐氟喹诺酮类基因nora的耐甲氧西林金黄色葡萄球菌sa1199B,本发明涉及的化合物与诺氟沙星联用能使诺氟沙星的mic值降低16倍,可进一步用于制备抗生素增效药物.

专利信息

专利号:US-6251689-B1
优先权日:1998-05-14
标 题:Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof
发明人：LABORDE EDGARDO; MATSUMOTO YUKIHARU
权利人:TELIK INC
摘要:The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.

专利号:WO-9707129-A1
优先权日:1995-08-18
标题 :Solution synthesis of peripheral acting analgesic opioid tetrapeptides
发明人：RINALDI NICHOLAS
权利人:IAF BIOCHEM INT; RINALDI NICHOLAS
摘要:This invention provides a bulk scale process for the solution synthesis of enantiomerically pure peripherally acting analgesic opioid tetrapeptides corresponding to formula (I): Tyr-(D)R1-R2-R3-NH2, where R1 is Ala or Arg; R2 is Phe or Phe(p-F); and R3 is Phe or Phe(p-F). A new and unique multi-step process is disclosed comprising the joining of two dipeptides using standard solution phase synthesis techniques, but adjusting the individual factors (e.g., solvents, activating agents, neutralizing agents etc.), to minimize racemization of the second amino acid. Tremendous cost efficiencies are achieved due to elimination of traditional sequential blocking-deblocking cycles and multiple chromatographic purification steps, which also enables these simple kilogram quantity methods to be scaled up to commercial production.

专利号:US-8101804-B2
优先权日:2006-07-28
标 题 :Process for the synthesis of (E)-stilbene derivatives which makes it possible to obtain resveratrol and piceatannol
发明人：SCHOUTEETEN ALAIN; JUS SEBASTIEN; VALLEJOS JEAN-CLAUDE
权利人:SCHOUTEETEN ALAIN; JUS SEBASTIEN; VALLEJOS JEAN-CLAUDE; CLARIANT SPECIALTY FINE CHEM F
摘要:A subject-matter of the present invention is a novel process for the synthesis of (E)-stilbene derivatives targeted at obtaining in particular resveratrol and piceatannol.

专利号:US-6121054-A
优先权日:1997-11-19
标 题 :Method for separation of liquid and solid phases for solid phase organic syntheses
发明人：LEBL MICHAL
权利人:TREGA BIOSCIENCES INC
摘要:A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed.

专利号:US-9581601-B2
优先权日:2011-05-18
标题:Method of detection of amino acid sequence and/or identification of peptides and proteins, by use of a new derivatization reagent and synthesis of 5-formyl-benzene-1,3-disulphonic acid as derivatization reagent
发明人：CINDRIC MARIO; HAMERSAK ZDENKO; DODIG IVANA
权利人:CINDRIC MARIO; HAMERSAK ZDENKO; DODIG IVANA; RUDJER BOSKOVIC INST
摘要:Present invention refers to a novel and improved method of derivatization and detection of amino acid sequence and/or identification of proteins, peptides by a new derivatization compound. Precisely, the method discloses a novel approach to derivatization of peptides or proteins by compounds comprising two or more sulfonyl groups and analysis of derivatized analytes in negative mode of operation of mass spectrometer. This method allows unambiguous analysis of amino acid sequence of long-chain peptides/proteins. Also, the invention discloses a novel synthesis procedure of 5-formyl-benzene-1,3-disulphonic acid as derivatization compound.

专利号:US-7705188-B2
优先权日:2002-04-10
标 题:Structural modification of resveratrol: sodium resverastatin phosphate
发明人：PETTIT GEORGE R; GREALISH MATTHEW P
权利人:UNIV ARIZONA
摘要:Described herein are novel compounds having antineoplastic and antimicrobial activity, obtained via structural modifications of resveratrol and combretastatin A-4, methods for synthesis of these compounds, and their use in pharmaceutical composition and for use in the treatment of mammals having cancer. Examples of the novel compounds are: (Z)- and (E)-3,4′,5-trimethoxystilbene (4a, 4b); (Z)- and (E)-3,5-dimethoxy-4′-hydroxystilbene (14c, 14d); (Z)- and (E)-3-hydroxy-4′,5-dimethoxystilbene (14g, 14h); (Z)- and (E)-3,5-dihydroxy-4′-methoxy-stilbene (14k, 14l); sodium resverastatin dibenzyl phosphate ((Z)-3,5-dimethoxy-4-[O-bis(benzyl)phosphoryl]-stilbene) (14m); and sodium resverastatin phosphate (14n).