CAS: 2651-43-6; 3-Hydroxypropanamide

相似化合物

109-78-4 156-87-6 7597-56-0

上下游产品

CAS号7597-56-0 氨基甲酰乙酸乙酯 | CAS号57-57-8 丙内酯 | CAS号109-78-4 3-羟基丙腈 | CAS号7664-41-7 氨 | CAS号497-25-6 2-恶唑烷酮 | CAS号107-13-1 丙烯腈 | CAS号140-88-5 丙烯酸乙酯 | CAS号79-06-1 丙烯酰胺 | CAS号13304-62-6 N-苄基丙烯酰胺 | CAS号3066-72-6 2-Propenamide,N... | CAS号1506-53-2 N-十二烷基丙烯酰胺

3-羟基丙腈置于manganese(Iv) Oxide,Silica Gel体系中,用 正己烷 用作溶剂,化学反应 192.0H,以92%的收率获得3-羟基丙酰胺
参考文献:腈温和水合为酰胺
标题:腈温和水合为酰胺
摘要:在室温下将几天内沉积在硅胶上的β-羟基腈与二氧化锰的混合物进行搅拌,导致以适当的收率形成了相应的酰胺.通过这种方法已经完成了3-羟基戊二腈向相应的单酰胺的前所未有的转化.
Doi:10.1016/s0040-4039(00)76229-0

专利信息

专利号:US-2006199958-A1
优先权日:2003-04-14
标 题 :Process and intermediates for the preparation of pyrrolidine carboxylic acids
发明人：CVETOVICH RAYMOND; CHUNG JOHN Y; AMATO JOSEPH S; DIMICHELE LISA
权利人:CVETOVICH RAYMOND; CHUNG JOHN Y; AMATO JOSEPH S; DIMICHELE LISA
摘要:A novel process is provided for the preparation of pyrrolidine carboxylic acids, and the useful intermediates obtained therein. These compounds are intermediates for the synthesis of melanocortin-4 receptor (MC-4R), which are useful for the treatment of disorders such as obesity, diabetes, sexual dysfunction, male sexual dysfunction, and female sexual dysfunction.

专利号:US-6191277-B1
优先权日:1998-04-29
标 题:Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases
发明人：DOLLE III ROLAND ELLWOOD; CAVALLARO CULLEN LEE; HERPIN TIMOTHEE FELIX
权利人:PHARMACOPEIA INC
摘要:Compounds of Formula Iare disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathsepsin D. The compounds are useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds of Formula I, Y is a heterocycle, amide, sulfonamide or carbamate and Z is an acyl or a functionalized acyl. Intermediates in the solid phase synthesis of compounds of Formula I, in which compounds are attached to a solid phase support, are also disclosed.

专利号:US-5144074-A
优先权日:1988-02-24
标 题:Process for the synthesis of carboxamides
发明人：LISTEMANN MARK L; PIERANTOZZI RONALD; ARMOR JOHN N
权利人:AIR PROD & CHEM
摘要:Carboxamides having the structural formula: n n R.sup.1 CHR.sup.2 CH(OR.sup.3)NHCR.sup.4 O n n wherein: n R 1 is H, C 1 -C 6 alkyl or aryl; n R 2 is H, C 1 -C 6 alkyl; n R 3 is benzyl, C 1 -C 8 alkyl or hydroxyalkyl; and n R 4 is H, C 1 -C 6 alkyl or aryl; n are synthesized by reacting an aldehyde having the structural formula: R 1 CHR 2 CHO wherein R 1 and R 2 are as defined above, with an alcohol having the structural formula: R 3 OH, wherein R 3 is as defined above, and an amide having the structural formula: R 4 CONH 2 wherein R 4 is as defined above, in the presence of a strong acid catalyst at a temperature in the range of 0°-200° C.

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:US-10772971-B2
优先权日:2017-06-22
标 题:Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
发明人：GURIJALA VENU REDDY; BOLLU SATYANARAYAN REDDY; LEBLANC JACQUES; LOWINGER TIMOTHY B; MCGILLICUDDY DENNIS; YIN MAO; YURKOVETSKIY ALEKSANDR V
权利人:MERSANA THERAPEUTICS INC; MERSANA THERPEUTICS INC
摘要:The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.

专利号:US-5635598-A
优先权日:1993-06-21
标 题:Selectively cleavabe linners based on iminodiacetic acid esters for solid phase peptide synthesis
发明人：LEBL MICHAL; KRCHNAK VIKTOR; KOCIS PETR; LAM KIT S
权利人:SELECTIDE CORP
摘要:The present invention is directed to linkers based on ester bond linkages, especially iminodiacetic acid ester bond linkages, for use in solid phase peptide synthesis. In particular, the invention is directed to cleavable linkers that can release peptide from the solid phase support under relatively mild conditions by formation of a diketopiperazine or other cyclic structure, such that the cyclic structure remains on the solid phase support, and, in a second cleavage, under more stringent conditions of high pH. The invention is further directed to solid phase supports prepared with multiple cleavable linkers, including a linker that is cleaved by formation of a cyclic product. One such second linker is an ester of hydroxymethylbenzoic acid, or esters formed by carboxy groups of aspartic or glutamic acid.