CAS: 50488-42-1; 2-Bromo-5-(Trifluoromethyl)Pyridine

相似化合物

1221272-81-6 55304-87-5 175205-82-0

上下游产品

CAS号52334-81-3 2-氯-5-三氟甲基吡啶 | CAS号73290-22-9 2-溴-5-碘吡啶 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号624-28-2 2,5-二溴吡啶 | CAS号142946-80-3 5,5'-二(三氟甲基)-2,... | CAS号188527-56-2 2-苯基-5-三氟甲基吡啶 | CAS号248274-16-0 1-(5-(三氟甲基)吡啶-2-基)乙酮 | CAS号80194-69-0 5-(三氟甲基)吡啶-2-甲酸 | CAS号31181-84-7 5-三氟甲基吡啶-2-甲醇 | CAS号95727-86-9 2-氰基-5-三氟甲基吡啶 | CAS号89570-85-4 2-肼基-5-三氟甲基砒啶 | CAS号74784-70-6 2-氨基-5-三氟甲基吡啶 | CAS号124236-37-9 5-三氟甲基吡啶-2-羧酸甲酯 | CAS号370878-65-2 2-(3-Methoxyphe...

2-氯-5-三氟甲基吡啶置于三甲基溴硅烷体系中,用 Various Solvent(S) 作为反应溶剂,化学反应 20.0H,以76%的收率获得产物2-溴-5-(三氟甲基)吡啶
参考文献:三氟甲基取代的吡啶羧酸和喹啉羧酸的推荐路线
标题:三氟甲基取代的吡啶羧酸和喹啉羧酸的推荐路线
摘要:作为案例研究的一部分,准备的合理策略.所有 10 种 2-,3-或 4-吡啶羧酸和所有 9 种在 2-,3-或 4-位带有三氟甲基取代基的 2-,3-,4-或 8-喹啉羧酸中的 如果前体中尚未存在三氟甲基,则通过用四氟化硫对合适的羧酸进行脱氧氟化或通过原位反应生成的三氟甲基铜置换环结合的溴或碘来引入三氟甲基.羧基功能是通过用二氧化碳处理有机锂或有机镁中间体,卤素/金属或氢/金属置换的产物而产生的.[在 Scifinder (R) 上]
DOI:10.1002/ejoc.200390215

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues