CAS: 59-48-3; Indolin-2-One

上下游产品

CAS号91-56-5 靛红 | CAS号120-72-9 吲哚 | CAS号30095-98-8 (2-硝基苯基)乙酸甲酯 | CAS号3740-52-1 2-硝基苯乙酸 | CAS号5339-85-5 2-氨基苯乙醇 | CAS号628-21-7 1,4-二碘丁烷 | CAS号109-72-8 正丁基锂 | CAS号110-18-9 四甲基乙二胺(TEMED) | CAS号2365-44-8 2-羰基二氢吲哚-3-腙 | CAS号65816-14-0 1,3-dihydro-1-M... | CAS号496-30-0 2-吲哚啉硫酮 | CAS号496-15-1 二氢吲哚 | CAS号3342-78-7 2-氨基苯乙酸 | CAS号607-28-3 β-衣托肟[用于金属分析] | CAS号3335-98-6 N-苯基吲哚酮 | CAS号3416-18-0 5-羟基吲哚-2-酮 | CAS号14370-71-9 Acetic acid,2-(... | CAS号141210-63-1 3-(dimethylamin... | CAS号479-41-4 靛玉红

9-Methyl-9H-Fluorene-9-Carbonyl Chloride置于盐酸,一水合肼,1,8-二氮杂双环[5.4.0]十一碳-7-烯,Bis(Dibenzylideneacetone)-Palladium(0),Tri Tert-Butylphosphoniumtetrafluoroborate体系中,用 四氢呋喃,甲醇,水 作为反应溶剂,化学反应 41.0H,反应生成 2-吲哚酮
参考文献:钯催化双羰基化方法从 2-碘苯胺制备靛红
标题:钯催化双羰基化方法从 2-碘苯胺制备靛红
摘要:已开发出合成靛红的高产程序.用接近化学计量的 Co 对 2-碘苯胺进行连续 Pd 催化双羰基化,然后进行酸促进环化,很容易得到一系列靛红.发现 2-碘苯胺以非常好到极好的产率转化为靛红,具有非常好的官能团耐受性.该协议证明适用于靛红的 13C 同位素标记,并扩展到 13C 同位素标记的抗病毒药物美替沙宗和实验性抗精神分裂症药物 Ml137 的合成.
DOI:10.1002/ejoc.201600143

专利信息

专利号:WO-2023233371-A1
优先权日:2022-06-03
标 题:A continuous flow process for synthesis of organic azides
发明人：GNANAPRAKASAM BOOPATHY; PANDEY AKANKSHA M; MONDAL SHANKHAJIT
权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES PUNE IISER PUNE
摘要:The present disclosure relates generally to the field of synthetic organic chemistry. More specifically, the disclosure is directed to a continuous flow process for synthesis of azides from alcohols and peroxides, wherein the process comprises azidation with trimethylsilyl azide and a catalyst Amberlyst-15. It is a non-hazardous, mild and controlled reaction giving good yields of azides. The azides can be further employed for synthesis of medicinally and industrially useful chemicals.

专利号:WO-2021260722-A1
优先权日:2020-06-21
标 题:Design, synthesis of novel oxyindole inhibitors of denv rna dependent rna polymerase
发明人：GUNDLA RAMBABU; ASTHANA SHAILENDRA; BHATTACHARYYA SANKAR; MADDIPATI VENKATANARAYANA CHOWDARY; MITTAL LOVIKA; KAUR JASKARAN; RAWAT YOGITA
权利人:TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE; GANDHI INSTITUTE OF TECH AND MANAGEMENT
摘要:The present invention is drawn to novel compounds of formula I, II and III, including any conformational isomeric form, salts and solvates for inhibition of DENV RNA dependent and RNA polymerase. The present invention also discloses a process of synthesis of the compounds, compositions comprising the said compounds and use of the compounds and treatment comprising the compounds of the present invention.

专利号:US-8822702-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof
发明人：BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

专利号:US-5840915-A
优先权日:1990-01-22
标题:Process for the enatioselective synthesis of intermediates used
发明人：LEE THOMAS BING KIN; WONG GEORGE SEUNG-KIT
权利人:HOECHST MARION ROUSSEL INC
摘要:A process for the stereoselective synthesis of [R]- and [S]-2,3-dihydro-1,3-dimethyl-2-oxo-1H-indole-3-acetonitriles comprises reacting racemic and 5-alkoxy-substituted (+/-)-1,3-dimethyloxindoles with a halogenated acetonitrile in the presence of a substituted N-benzyl cinchoninium, quinidinium, cinchonidinium, or quininium catalyst. The resulting alkylated oxindoles can be converted to primary amines by catalytic reduction in the presence of hydrogen gas. One of the primary amines, such as enantiomers of 3-(2-aminoethyl)-1,3-dihydro-1,3-dimethyl-5-methoxy-2H-indol-2-one, can be enriched by contact with a chiral tartaric acid in an amount sufficient to preferentially precipitate a salt of the chiral acid and one of the enantiomers. The product can be used in the synthesis of stereospecific forms of physostigmine and related compounds having pharmaceutical activity.

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:WO-2023102600-A1
优先权日:2021-12-06
标题:Synthesis of amphiphilic block copolymers and polymeric nanofibers produced therefrom
发明人：ZETTERLUND PER B; ISHIZUKA FUMI; KIM HYUN JIN; CHATANI SHUNSUKE; NIINO HIROSHI
权利人:NEWSOUTH INNOVATIONS PTY LTD
摘要:The present disclosure relates to the field of synthesis of block copolymers, and polymeric nanofibers having a core-shell morphology produced therefrom. The present disclosure relates to the field of synthesis of block copolymers where one block is more hydrophobic than the other block and is a different composition. The disclosure also relates to uses of these polymeric nanofibers in various applications, such as reinforcing a polymeric matrix and for coatings applications.