CAS: 611-17-6; 1-(Bromomethyl)-2-Chlorobenzene

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CAS号95-49-8 邻氯甲苯 | CAS号17849-38-6 2-氯苄醇 | CAS号89-98-5 邻氯苯甲醛 | CAS号611-19-8 邻氯氯苄 | CAS号1058649-12-9 2-chloro-1-(met... | CAS号506-68-3 溴化氰 | CAS号10175-31-2 BENZENEMETHANAM... | CAS号65763-39-5 (2-chloro-benzy... | CAS号52803-70-0 2-(2-氯苄氧基)-苯甲酸 | CAS号53389-99-4 2-(2-氯苄氧基)苯甲醛 | CAS号94-64-4 N-甲基-2-氯苄胺 | CAS号17849-38-6 2-氯苄醇 | CAS号68578-51-8 chloro-1 ethoxy... | CAS号56427-98-6 1-chloro-2-[(2-... | CAS号89-98-5 邻氯苯甲醛 | CAS号32442-74-3 1-(2-chlorophen... | CAS号10175-31-2 BENZENEMETHANAM... | CAS号3047-25-4 4-(2-Chlorophen...

2-氯甲苯置于n-溴代丁二酰亚胺(Nbs),过氧化苯甲酰体系中,用 四氯化碳 作为反应溶剂,化学反应 6.0H,反应生成 2-氯苄溴
参考文献:钯催化芳烃羧酸/酯与芳基溴化物的分子内脱羧偶联
标题:钯催化芳烃羧酸/酯与芳基溴化物的分子内脱羧偶联
摘要:给我一个戒指已经开发出一种有效的方法用于芳烃羧酸/酯与钯催化的芳基溴化物的分子内脱羧偶联(参见方案).从合成的观点来看,该方法极具吸引力,因为催化剂的负载量低,优化的反应条件温和且底物范围广.
DOI:10.1002/chem.201103438

专利信息

专利号:US-7102023-B2
优先权日:1999-11-24
标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
发明人：BUCHWALD STEPHEN L; PLANTE OBADIAH J; SEEBERGER PETER H
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.

专利号:US-6133409-A
优先权日:1996-12-19
标 题:Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

专利号:EP-0946478-B1
优先权日:1996-12-19
标题 :Process for the solid phase synthesis of aldehydes, ketones and hydroxamic acid compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARMA INC
摘要:This invention is directed to processes for the solid-phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds and to polymeric hydroxylamine resin compounds useful therefor.

专利号:US-6710208-B2
优先权日:1996-12-19
标题 :Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARMA INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

专利号:US-2013274466-A1
优先权日:2010-09-27
标 题:Process for the preparation of tetracyclic derivatives and intermediate products used in the process
发明人：GORIN BORIS; DIXON CRAIG EDWARD; QU YANG
权利人:GORIN BORIS; DIXON CRAIG EDWARD; QU YANG; ALPHORA RES INC
摘要:A process for preparation of a compound of formula I or a pharmaceutically acceptable salt thereof, is disclosed. The process involves subjecting a compound of formula II to Ullmann-type conditions to effect an intra-molecular ring closure reaction to form the compound of formula I. The different substituents are as described in the specification. Further, the process can provide an alternate route for the synthesis of asenapine from starting materials that can be readily available.

专利号:US-2005130228-A1
优先权日:2000-03-17
标题:Dosing form for a polymer support, use of said dosing form in organic chemical synthesis and method for production of said dosing form
发明人：RUHLAND THOMAS; HOLM PER; SCHULTZ KIRSTEN; HOLM JANNIE E; ANDERSEN KIM
权利人:LUNDBECK & CO AS H
摘要:A dosing form for a polymer support for organic chemical synthesis in a solvent medium comprising a fixed weight amount of beads of a polymer containing functional groups, which polymer is insoluble in the solvent for the intended synthesis, is provided as compressed tablets of essentially equal weight and composition wherein the polymer beads are essentially intact and are released as such when the tablets are disintegrated in said solvent. Use of the dosing form is made in conventional synthesis, in parallel synthesis, in split and mix synthesis and/or combinatorial chemistry. In a method for producing the dosing form, beads of a polymer having functional gropusgroups is compressed into tablets after pre-treatment with an aprotic organic solvent. groups are compressed into tablets after pre-treatment with an aprotic organic solvent.