CAS: 635-46-1; 1,2,3,4-Tetrahydroquinoline

相似化合物

123387-53-1 58960-03-5 91-61-2

上下游产品

3,4-二氢-2(1H)-喹啉酮 3,4-Dihydro-2(1H)-Quinolone 553-03-7
1-甲基-1,2,3,4-四氢喹啉 N-Methyl-1,2,3,4-Tetrahydroquinoline 491-34-9
3,4-Dihydro-(1H)-Quinoline-2-Thione 41493-89-4
2,3-二氢-1H-喹啉-4-酮 2,3-Dihydroquinolin-4(1H)-One 4295-36-7
1-Butyl-1,2,3,4-Tetrahydroquinoline 6613-30-5
2-甲基吲哚啉 2-Methyl Indoline 06/06/6872
3,4-Dihydro-2H-Quinoline-1-Carbaldehyde 2739-16-4
1-Allyl-1,2,3,4-Tetrahydroquinoline 80574-15-8
6-溴-1,2,3,4-四氢-2-喹啉酮 6-Bromo-3,4-Dihydro-1H-Quinolin-2-One 3279-90-1
1-Prenyl-1,2,3,4-Tetrahydroquinoline 88342-89-6

3-烯丙基-2-羟基苯甲酸甲酯置于盐酸,Sodium Hydroxide,氯化亚砜,三氟化硼四氢呋喃络合物,水,双氧水,Sodium Hydride,三乙胺,肼,Lithium Diisopropyl Amide体系中,用 四氢呋喃,二氯甲烷,水,N,N-二甲基甲酰胺,叔丁醇 作为反应溶剂,化学反应 45.75H,反应生成 1,2,3,4-四氢喹啉
参考文献:Nucleophilic Annulations Of Aromatics. Novel Route To Benzo-Fused Ring Systems Via Oxazoline Activation
标题:Nucleophilic Annulations Of Aromatics. Novel Route To Benzo-Fused Ring Systems Via Oxazoline Activation
摘要:
DOI:10.1021/jo00317A027

专利信息

专利号:US-8822702-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof
发明人：BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2024092821-A1
优先权日:2020-03-31
标题:Synthesis of oligonucleotides and related compounds
发明人：ZHONG MINGHONG; JIN YI; GALA DINESH; PRHAVC MARIJA
权利人:JANSSEN BIOPHARMA INC
摘要:Methods of synthesizing oligonucleotides via new intermediates on a cleavable support having an azidomethyl moiety are disclosed. The method comprises multiple reaction cycles, each of which comprises sequential coupling a nucleoside or oligonucleotide subunit on a cleavable support having an azidomethyl moiety and a nucleoside phosphoramidite or an oligonucleotide phosphoramidite, capping, oxidation/thiolation and deblocking; followed by orthogonal cleavage of the azidomethyl support while keeping all other protecting groups intact. The method can be used in combination with a support moiety for either solid phase or liquid phase oligo synthesis. The soluble support facilitates homogeneous reactions and efficient separations by simple precipitation. The methods also provide novel intermediates useful in the synthesis of oligonucleotide conjugates.

专利号:US-4902817-A
优先权日:1987-09-17
标 题 :Process for the synthesis of alpha n alkylated amino acids and esters thereof, application to the synthesis of carboxyalkyl dipeptides
发明人：VINCENT MICHEL; BALIARDA JEAN; MARCHAND BERNARD; REMOND GEORGES
权利人:ADIR
摘要:Stereoselective process for the industrial synthesis of compounds of formula (I): ##STR1## where R 1 is linear or branched lower alkyl with 1 to 6 carbon atoms, n R 2 is a linear or branched lower alkyl with 1 to 4 carbon atoms, n employing inexpensive starting materials and obtaining optimum yields. n Application to the synthesis of carboxyalkyl dipeptides.

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-2012302756-A1
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines
发明人：LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.