CAS: 637-59-2; (3-Bromopropyl)Benzene

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CAS号122-97-4 3-苯丙醇 | CAS号866942-18-9 3-phenylpropyl ... | CAS号3742-75-4 3-Phenylpropyl ... | CAS号1082742-89-9 3-phenylpropyl ... | CAS号501-52-0 3-苯丙酸 | CAS号866942-16-7 3-phenylpropyl ... | CAS号109398-68-7 4-methylbenzene... | CAS号100708-34-7 1-(3-iodopropyl... | CAS号107100-64-1 N-苯丙基-4-哌啶酮 | CAS号36329-85-8 3-苯基丙基硼酸 | CAS号329685-40-7 3-苯基-1-丙基硼酸频哪酯 | CAS号1087-49-6 1,6-二苯己烷 | CAS号55455-92-0 苯基丙基哌嗪 | CAS号14289-73-7 (3-propoxypropy...

环丙基苯置于三溴化硼,叔丁醇体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.0H,以77%的收率获得产物1-溴-3-苯基丙烷
参考文献:三溴化硼作为反马氏化学物质向环丙烷中添加hbr的试剂
标题:三溴化硼作为反马氏化学物质向环丙烷中添加hbr的试剂
摘要:尽管由三烷基硼烷形成自由基的记载已得到充分证明,但对于三卤硼烷而言,类似的反应模式尚不清楚.我们发现在开放烧瓶条件下,三溴化硼和简单的质子源(例如水或叔丁醇)会反应生成溴自由基.带有多种取代基的环丙烷被氢溴和氘代溴化,以高度区域选择性的方式提供了反马尔可夫尼科夫产品.NMR机理研究和dft计算指向自由基途径,而不是bbr 3预期的常规离子机理.
DOI:10.1039/d0Sc02567D

专利信息

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-10889599-B2
优先权日:2018-02-27
标 题:1,1-diborylalkyl-1-metal compounds, preparation method thereof, and their applications toward synthesis of 1,1-diboronate ester compounds
发明人：CHO SEUNG HWAN; LEE YEOSAN
权利人:POSTECH ACAD IND FOUND
摘要:The present invention relates to a 1,1-diborylalkyl-1-metal compound including one metal group together with two identical boron groups at the sp3 carbon center, and its use. Specifically, the present invention relates to development of novel organic reactions, synthesis of functional molecules, and synthesis of new drugs by applying the novel 1,1-diboryl-1-metal substituted alkyl compounds to various molecular libraries which could not be synthesized by conventional methodologies.

专利号:US-7250510-B2
优先权日:2005-08-24
标 题:Transition metal complexes of N-heterocyclic carbenes, method of preparation and use in transition metal catalyzed organic transformations
发明人：ORGAN MICHAEL G; O'BRIEN CHRISTOPHER J; KANTCHEV ASSAM ERIC B
权利人:TOTAL SYNTHESIS LTD
摘要:The present invention relates to catalysts of transition metal complexes of N-heterocyclic carbenes, their methods of preparation and their use in chemical synthesis. The synthesis, ease-of-use, and activity of the compounds of the present invention are substantial improvements over in situ catalyst generation. Further, the transition metal complexes of N-heterocyclic carbenes of the present invention may be used as precatalysts in metal-catalyzed cross-coupling reactions.

专利号:US-6423871-B1
优先权日:1999-02-26
标题 :Efficient synthesis of secondary amines by selective alkylation of primary amines
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23° C.; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73% yield.

专利号:WO-0050377-A1
优先权日:1999-02-26
标 题:Efficient synthesis of secondary amines by selective alkylation of primary amines
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23 °C; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73 % yield.

专利号:WO-2007005037-A1
优先权日:2005-06-30
标 题 :Process for synthesis of diorganosilanes by disproportionation of hydridosiloxanes
发明人：RUBINSZRAJN SLAWOMIR; CELLA JAMES ANTHONY; CHOJNOWSKI JULIAN; FORTUNIAK WITOLD; KURJATA JAN
权利人:GEN ELECTRIC; RUBINSZRAJN SLAWOMIR; CELLA JAMES ANTHONY; CHOJNOWSKI JULIAN; FORTUNIAK WITOLD; KURJATA JAN
摘要:The present invention provides a novel method for the preparation of diorganosilanes by disproportionation of a hydridosiloxanes comprising at least one terminal SiH group and at least one siloxane bond in the presence of Lewis acid catalysts. The reaction is both selective and occurs under mild conditions. The triaryl borane, tris(petafluorophenyl)borane, is especially suited for use as a catalyst in the reaction. Organic catalysts such as tris(pentafluorophenyl)borane are typically preferred owing to their greater solubility and stability in the reaction mixture, relative to inorganic Lewis acid catalysts. The product, diorganosilane may be isolated from the product mixture by conventional techniques such as distillation.