对甲苯甲醚置于sodium Persulfate,Copper Diacetate,Sodium Acetate体系中,用 溶剂黄146 用作溶剂,以77%的收率获得4-甲氧基苄基乙酸酯 参考文献:Benzyl Acetates By Acetoxylation Of Methylbenzenes Using Peroxydisulfate As Oxidizing Agent 标题:Benzyl Acetates By Acetoxylation Of Methylbenzenes Using Peroxydisulfate As Oxidizing Agent 摘要: Doi:10.1055/s-1980-29061
专利信息
专利号:US-5446158-A 优先权日:1989-01-11 标题:Process for synthesis of FK-506 and tricarbonyl intermediates 发明人:JONES TODD K; MILLS SANDER G; ASKIN DAVID; REAMER ROBERT A; DESMOND RICHARD; TSCHAEN DAVID M; VOLANTE RALPH P; SHINKAI ICHIRO 权利人:MERCK & CO INC 摘要:A process is described for the total synthesis of the macrolide immunosuppressant, FK-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.
专利号:US-8829184-B2 优先权日:2010-04-15 标题:Intermediates useful for the synthesis of pyrrolobenzodiazepines 发明人:HOWARD PHILIP WILSON; MASTERSON LUKE; TIBERGHIEN ARNAUD 权利人:HOWARD PHILIP WILSON; MASTERSON LUKE; TIBERGHIEN ARNAUD; SPIROGEN SARL 摘要:A compound of formula (I): which is substantially free of any of the corresponding compound of formula (IB): methods of making such compounds, and the further transformation of such compounds.
专利号:WO-2023177866-A1 优先权日:2022-03-18 标题 :Decarboxylative acetoxylation using mn(ii) or mn(iii) reagent for synthesis of 4'-acetoxy- nucleoside and use thereof for synthesis of corresponding 4'-(dimethoxyphosphoryl)methoxy- nucleotide
专利号:US-6271345-B1 优先权日:1996-07-03 标 题 :Enzyme cleavable linker bound to solid phase for organic compound synthesis 发明人:WALDMANN HERBERT; SAUERBREI BERND; GRETHER UWE 权利人:BASF AG 摘要:An enzyme cleavable linker is prepared on which organic compounds are synthesized when the linker is bound to a solid phase. The linker contains a functional group on which a synthesized organic compound is bound when synthesis takes place, and a recognition site for a hydrolytic enzyme. Reacting the linker with the enzyme causes the linker to fragment at a site different from the recognition site to liberate the synthesized organic compound. The solid phase may be a crosslinked polyacrylamide containing an amino group for attaching the linker, and the linker is bound to the solid phase via a spacer. The spacer is attached to the solid phase by an ester, ether, amide or amine linkage, or a sulfide or phosphate linkage. In a specific reaction of forming a solid phase containing the linker, 2-acetoxy-5-hydroxymethylbenzoic acid is attached to an amino group-containing polymer via a spacer followed by conversion to a chloroformic ester.
专利号:US-4996314-A 优先权日:1986-03-11 标题 :6-(disubstituted amino)carbapenem compounds 发明人:YOSHIOKA TAKEO; CHIDA NORITAKA; WATANABE AZUMA; FUKAGAWA YASUO; ISHIKURA TOMOYUKI 权利人:SANRAKU INC 摘要:A compound represented by the formula ##STR1## wherein R 1 represents a lower alkyl group or a lower haloalkyl group; R 2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR 4 or --SO 2 R 5 in which R 4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R 5 represents an alkyl group or a substituted or unsubstituted aryl group; and R 3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic. n The compounds of the formula ##STR2## wherein R 1 and R 2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.
专利号:US-2013035484-A1 优先权日:2010-04-15 标 题:Intermediates useful for the synthesis of pyrrolobenzodiazepines
摘要:Folgueiras-Amador, A. A.; Hodgson, J. W.; Brown, R. C. D., Science of Synthesis: Special Topics, (2021) 1, 424. 参考文献:10.1038/nchem.1506 摘要:Over B, Wetzel S, Grütter C, Nakai Y, Renner S, Rauh D, Waldmann H. Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem. 2013 Jan;5(1):21–8. doi: 10.1038/nchem.1506. 参考文献:10.1007/s12551-018-0423-6 摘要:Meyer L, von Langermann J, Kragl U. Recent developments in biocatalysis in multiphasic ionic liquid reaction systems. Biophysical Reviews. 2018 Apr 27;10(3):901–10. doi: 10.1007/s12551-018-0423-6.