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D-亮氨酸置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应生成N-Boc-D-亮氨醇
参考文献:具有手性烷基化咪唑烷环的吡虫啉衍生物的合成及其杀虫活性和对烟碱乙酰胆碱受体的亲和性评估
标题:具有手性烷基化咪唑烷环的吡虫啉衍生物的合成及其杀虫活性和对烟碱乙酰胆碱受体的亲和性评估
摘要:不对称合成了一系列具有烷基化咪唑烷环的吡虫啉(imi)衍生物,以评估其对成年雌性家蝇musca Domestica的杀虫活性以及对果蝇的烟碱乙酰胆碱受体的亲和力.烷基越大,受体亲和力越低,但是在咪唑烷环的r-5-位甲基化和乙基化的衍生物与未取代的化合物等价.受体亲和力的定量结构-活性关系(qsar)分析表明,将取代基引入咪唑烷环基本上是不利的,但在r处引入取代基如果尺寸较小,则允许-5-位置.合成衍生物与受体的结合模型支持qsar分析,表明在配体结合位点r-5-位置周围的短烷基存在空间.此外,在杀虫活性和受体亲和力之间观测到正相关,这表明即使修饰了咪唑烷环,受体亲和力也是影响杀虫活性的主要因素.
Doi:10.1016/j.Bmc.2012.09.007

专利信息

专利号:US-8129411-B2
优先权日:2005-12-30
标题:Organic compounds
发明人：EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI
权利人:EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. n The compounds have the formula I′ n nwherein R1, R2, T, R3 and R4 are as defined in the specification.