CAS: 13808-64-5; 4-Bromo-3-Methylpyrazole

相似化合物

1021919-24-3 3398-16-1 288246-16-2

上下游产品

4-bromo-3-methyl-1-phenylsulphonylpyrazole 3-Methylpyrazole 4-bromo-1,3-dimethyl-1H-pyrazole 4-bromo-1,5-dimethyl-1H-pyrazole 3,4-dibromo-5-methylpyrazole 3-methyl-4-nitro-1H-pyrazole

3-甲基吡唑置于溴,Sodium Acetate,溶剂黄146体系中,用 水 用作溶剂,以79.5%的收率获得4-溴-3-甲基吡唑
参考文献:直接证明 4-Bromo-3(5)-Methylpyrazoles 的互变异构性质
标题:直接证明 4-Bromo-3(5)-Methylpyrazoles 的互变异构性质
摘要:互变异构是吡唑的关键特征,它与吡唑中两个氮之间的氢转移有关.学术界普遍接受的是,除了某些极端条件外,3(5)-取代吡唑衍生物的互变异构体不能作为单独的化合物分离.在这里,利用 N-取代抑制互变异构化并允许它们分离和分离的事实,合成,分离和进一步修饰了 3(5)-吡唑的 N-丙酸酯的单个异构体,并进一步修改了数次而不改变初始 3-或 5-甲基构型.然而,一旦去除了与氮相连的基团,两个单独的异构体就恢复了它们的互变异构体特性,并成为相同的互变异构体混合物,正如预期的那样.通过 NMR 光谱的密切监测生动地证明了 3(5)-吡唑衍生物的互变异构特性的损失,然后沿着旨在可能分离两个互变异构体的化学转化集恢复.未能分离它们再次证明溶液中互变异构体的动态平衡是3(5)-甲基吡唑的固有特性.
Doi:10.1002/jhet.4529

专利信息

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-2018222892-A1
优先权日:2012-07-03
标 题 :Heterocyclic modulators of lipid synthesis

专利号:EP-3083583-B1
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof

专利号:CA-2934251-A1
优先权日:2013-12-20
标题:A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer

专利号:EP-3083583-A1
优先权日:2013-12-20
标题 :Heterocyclic modulators of lipid synthesis and combinations thereof