CAS: 186498-02-2; (4-Morpholinophenyl)Boronic Acid

上下游产品

4-bromophenyl-morpholine 1,4-bromoiodobenzene 1-acetyl-7-[4-(N-morpholino)phenyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid 4'-morpholin-4-yl-4-trifluoromethoxy-biphenyl-3-carboxylic acid [2-cyano-1-(1H-indol-3-ylmethyl)-ethyl]-amide N-(4-(2-methylpyridin-4-yl)phenyl)-2-(6-(4-morpholinophenyl)pyridin-2-yl)propanamide

4-(4-溴苯基)吗啉置于正丁基锂,硼酸三异丙酯体系中,用 四氢呋喃,乙酸乙酯,正戊烷 用作溶剂,化学反应生成4-吗啉苯硼酸
参考文献:Rho-Kinase Inhibitors
标题:Rho-Kinase Inhibitors
摘要:公开了化合物及其衍生物,它们的合成,以及它们作为rho激酶抑制剂的应用.本发明的这些化合物可用于抑制肿瘤生长,治疗勃起功能障碍,以及治疗其他由rho激酶介导的疾病,例如冠心病.

专利信息

专利号:US-11767302-B2
优先权日:2020-10-01
标题 :Reagents and methods for tetrazine synthesis
发明人：FOX JOSEPH M; LAMBERT WILLIAM; FANG YINZHI; AM ENDE CHRISTOPHER WILLIAM; MAHAPATRA SUBHAM; XIE YIXIN; WANG CHUANQI
权利人:UNIV DELAWARE
摘要:Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.

专利号:US-7585875-B2
优先权日:2006-06-06
标 题 :Substituted pyrazolo[1,5-a]pyridine compounds and their methods of use
发明人：GAETA FEDERICO C A; GROSS MATTHEW; JOHNSON KIRK W
权利人:AVIGEN INC
摘要:The present invention is directed to substituted pyrazolo[1,5-a]pyridines and related methods for their synthesis and use.

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.

专利号:US-7648986-B2
优先权日:2002-01-10
标题:Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors
发明人：NAGARATHNAM DHANAPALAN; KHIRE UDAY; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; WANG CHUNGUANG; HART BARRY; WEBER OLAF; LYNCH MARK; ZHANG LEI; WANG LEI
权利人:BAYER HEALTHCARE LLC
摘要:Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.