乙二醇置于sodium体系中,化学反应生成乙二醇单正丙醚 参考文献:The Importance Of Aesthetics In Body Dysmorphic Disorder 标题:The Importance Of Aesthetics In Body Dysmorphic Disorder 摘要:摘要 假设身体畸形障碍(bdd)患者首先更具 "美感",这种特质很像音乐感,因人而异.与健康人相比,这将导致他们对更具吸引力的个体产生更大的情感反应,并更加重视外表在身份认同中的重要性.一些 Bdd 患者可能具有更强的审美感知能力.这表现在他们接受过艺术和设计方面的教育或培训.其次,Bdd 患者的审美标准可能高于其他人群.他们无法达到不切实际的审美标准是 Bdd 的核心,导致严重的痛苦和障碍. Doi:10.1017/s1092852900017922
专利号:US-2023312617-A1 优先权日:2020-07-25 标题 :Process for synthesis of organosilicon compounds from halosilanes 发明人:DOLAI SUKANTA; BHAT SHREEDHAR; TARAFDAR GOURAV 权利人:MOMENTIVE PERFORMANCE MAT INC 摘要:A process for synthesis of an organosilicon compound is provided herein. Also, novel organosilicon compounds prepared by the present process is provided herein. The process comprises the reaction of a halosilane with an organofunctional alkyl halide in the presence of a metal catalyst, a promoter, and an optional co-catalyst. The process provides an efficient synthetic route to produce organosilicon compounds. The process also allows synthesis of organosilicon compounds with a plurality of different functional groups.
专利号:US-10065985-B2 优先权日:2015-02-03 标题 :Method for fully automated synthesis of 16β-18F-fluoro-5α-dihydrotestosterone (18F-FDHT) 发明人:MURPHY JENNIFER MARIE; LAZARI MARK SAUL 权利人:UNIV CALIFORNIA 摘要:The automated synthesis of clinically relevant amounts of 16β- 18 F-fluoro-5α-dihydrotestosterone ( 18 F-FDHT) using a commercially available radiosynthesizer. Synthesis was performed in 90 minutes with a decay-corrected radiochemical yield of 29±5%. The specific activity was 4.6 Ci/μmol (170 GBq/μmol) at end of formulation with a starting activity of 1.0 Ci (37 GBq). The formulated 18 F-FDHT yielded sufficient activity for multiple patient doses and passed all quality control tests required for routine clinical use.
专利号:US-10696622-B2 优先权日:2016-08-29 标题 :Synthesis of N-vinyl carboxylic acid amides 发明人:DUMOLEIJN KIM; MOONEN KRISTOF; Henricot Alexis; Han Cai Xing Simon 权利人:TAMINCO BVBA; EASTMAN CHEM CO 摘要:Processes and systems for producing N-vinyl carboxylic acid amides are provided herein. According to some aspects of the present invention, a process for producing an N-vinyl carboxylic acid amide is described that eliminates interim solids handling steps during formation of the intermediate compounds, thereby increasing efficiency and reducing cost. The processes and system described herein may be used for the synthesis of N-vinylformamide and its intermediates, including 1-hydroxyethylformamide and 1-alkoxyethylformamide, or for the synthesis of N-methyl,N-vinylformamide and its intermediates, including N-methyl,1-hydroxyethylformamide and N-methyl,1alkoxyethylformamide.
专利号:US-8198465-B2 优先权日:2005-10-17 标 题 :3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors 发明人:SEDELMEIER GOTTFRIED; GRIMLER DOMINIQUE; ACEMOGLU MURAT 权利人:SEDELMEIER GOTTFRIED; GRIMLER DOMINIQUE; ACEMOGLU MURAT; NOVARTIS AG 摘要:The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, n nor a salt thereof, and a compound of formula VIn n nor a salt thereof, wherein R 3 and R 4 as well as Act are as defined in the specification, and processes of manufacturing these.n n Additionally transformation of compounds (VI) with metallo organic compounds (VII) give rise to the new compounds (VIII) which are direct precursors for the preparation of Aliskiren.
专利号:US-6646118-B2 优先权日:1996-08-30 标 题 :Solid phase synthesis 发明人:KWIATKOWSKI MAREK; NILSSON MATS; LANDEGREN ULF 权利人:QUIATECH AB 摘要:The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthesis of oligonucleotides on a solid support. The support system comprises a stable disiloxyl linkage providing high nucleoside loadings to the support and the method allows convenient non-laborious oligomer synthesis.
专利号:US-9487399-B2 优先权日:2010-08-17 标题 :Method for the synthesis of metallic nano products 发明人:GHANAVI JALALEDIN; MOSTAFAVI MEHRNAZ; GHANAVI ZOHRE 权利人:GHANAVI JALALEDIN; MOSTAFAVI MEHRNAZ; GHANAVI ZOHRE 摘要:The embodiments herein provide a method of synthesis for metallic nano-products such as metallic nano-antennas, metallic nano-rods, metallic nano-wires, metallic nano-prolate spheroids and metallic nano-oblate spheroids using saturated and unsaturated carboxylic acids. The method involves preparing a reaction mixture by mixing a polar protic solvent, a polar aprotic solvent or a non-polar solvent, a saturated fatty acid or an unsaturated fatty acid and a metallic salt. Then a mixture of reducing agents is prepared by mixing a polar protic solvent, a polar aprotic solvent or a non-polar solvent and a saturated fatty acid or an unsaturated fatty acid. The reaction mixture and the mixture of reducing agents are combined and heated solvo-thermally for a pre-determined period of time at a pre-determined temperature.
[参考文献]: G V Katz, Et Al. Comparative Acute And Subchronic Toxicity Of Ethylene Glycol Monopropyl Ether And Ethylene Glycol Monopropyl Ether Acetate. Environ Health Perspect. 1984 Aug:57:165-75. [参考文献]: Jochem Louisse, Et Al. The Use Of In Vitro Toxicity Data And Physiologically Based Kinetic Modeling To Predict Dose-Response Curves For In Vivo Developmental Toxicity Of Glycol Ethers In Rat And Man. Toxicol Sci. 2010 Dec;118(2):470-84. [参考文献]: R Loch-Caruso, Et Al. Interruption Of Cell-Cell Communication In Chinese Hamster V79 Cells By Various Alkyl Glycol Ethers: Implications For Teratogenicity. Environ Health Perspect. 1984 Aug:57:119-23. [参考文献]: W J Krasavage, Et Al. Developmental Toxicity Of Ethylene Glycol Monopropyl Ether In The Rat. Teratology. 1985 Aug;32(1):93-102.
合成参考文献
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