专利号:US-5767211-A 优先权日:1996-05-02 标 题:Synthesis of multi-functional hyperbranched polymers by polymerization of di-or tri-vinyl monomers in the presence of a chain transfer catalyst 发明人:GUAN ZHIBIN 权利人:DU PONT 摘要:This invention concerns the synthesis of multi-functional hyperbranched polymers by free radical polymerization of di- or tri-vinyl monomers in the presence of a chain transfer catalyst and a non-peroxide free radical initiator. The low viscosity and high functionality of these polymers make them useful for automotive coatings and for photopolymerization applications.
专利号:EP-2128179-B1 优先权日:2008-05-26 标 题:Solid-phase support for nucleic acid synthesis 发明人:MORI KENJIRO; MAETA ERI 权利人:NITTO DENKO CORP 摘要:According to the invention, there is provided a solid-phase support for nucleic acid synthesis, which is constituted of a porous copolymer particle containing a multifunctional vinyl monomer unit having two or more vinyl groups in one molecule and a monofunctional vinyl monomer unit having one vinyl group in one molecule, in which the solid-phase support has a swelling volume when soaked in acetonitrile of 3.5 ml/g or more and has a median particle diameter measured by a laser scattering particle size distribution measuring method within a range of from 50 to 120 µm. According to the solid-phase support for nucleic acid synthesis of the invention, a high-purity nucleic acid can be synthesized with a high yield.
专利号:US-6392031-B1 优先权日:1995-11-27 标题 :Polymer supports for nucleic acid synthesis 发明人:TANG JIN-YAN; TANG JIMMY X 权利人:AVECIA BIOTECHNOLOGY INC 摘要:The invention provides passivated organic polymer supports, processes for their preparation and processes for their use in oligonucleotide synthesis that allow for highly efficient solid phase synthesis of oligonucleotides.
专利号:US-2024158826-A1 优先权日:2022-11-16 标 题 :Preparation method of synthetase for continuous monitoring of blood glucose 发明人:ZHANG SHAODA; QIU ZHIPENG; ZHENG XINGYU 权利人:ZHANG SHAODA; QIU ZHIPENG; ZHENG XINGYU 摘要:The present invention discloses a preparation method of a synthetase for continuous monitoring of blood glucose. The method includes the preparation steps of step S1: hydroxylation of a glass bead; step S2: silanization of the glass bead; step S3: bonding of the glass bead to glucose; step S4: synthesis of a polymer particle on the surface of the glass bead to form a glucose synthetase; and step S5: separation of the highly specific glucose synthetase. According to the preparation method of a synthetase for continuous monitoring of blood glucose provided by the present invention, the glass bead is bonded to the glucose by activating the surface of the glass bead, and then bonded to a polymer to form the glucose synthetase. The artificial synthetase prepared by the method has low sensitivity to temperature and pH value, and can be directly used in a blood glucose electrochemical sensor.
专利号:US-6251280-B1 优先权日:1999-09-15 标 题 :Imprint-coating synthesis of selective functionalized ordered mesoporous sorbents for separation and sensors 发明人:DAI SHENG; BURLEIGH MARK C; SHIN YONGSOON 权利人:UNIV TENNESSEE RES CORP; U T BATTELLE LLC 摘要:The present invention relates generally to mesoporous sorbent materials having high capacity, high selectivity, fast kinetics, and molecular recognition capability. The invention also relates to a process for preparing these mesoporous substrates through molecular imprinting techniques which differ from convention techniques in that a template molecule is bound to one end of bifunctional ligands to form a complex prior to binding of the bifunctional ligands to the substrate. The present invention also relates to methods of using the mesoporous sorbent materials, for example, in the separation of toxic metals from process effluents, paints, and other samples; detection of target molecules, such as amino acids, drugs, herbicides, fertilizers, and TNT, in samples; separation and/or detection of substances using chromatography; imaging agents; sensors; coatings; and composites.
专利号:US-7635772-B2 优先权日:2002-12-18 标 题 :Process for the preparation of oligonucleotides 发明人:MCCORMAC PAUL 权利人:AVECIA BIOTECHNOLOGY INC 摘要:A process for the synthesis of an oligonucleotide is provided in which an oligonucleotide is assembled on a swellable solid support using the phosphoramidite approach in the presence of an activator, wherein the activator is not tetrazole or a substituted tetrazole. Preferred activators are pyridinium, imidazolinium and benzimidazolinium salts; benzotriazole and derivatives thereof; and saccharin or a saccharin derivative. Preferred swellable solid supports comprise functionalised polystyrene, partially hydrolysed polyvinylacetate or poly(acrylamide).
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合成参考文献
参考文献:10.1007/s00216-011-5206-x 摘要:Gadzała-Kopciuch R, Cendrowski K, Cesarz A, Kiełbasa P, Buszewski B. Determination of zearalenone and its metabolites in endometrial cancer by coupled separation techniques. Analytical and Bioanalytical Chemistry. 2011 Jul 13;401(7):2069. doi: 10.1007/s00216-011-5206-x.