CAS: 5409-31-4; 3,4-Diethoxybenzoic Acid

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CAS号99-50-3 原儿茶酸 | CAS号75-03-6 碘乙烷 | CAS号2029-94-9 3,4-二乙氧基苯甲醛 | CAS号75332-44-4 3,4-二乙氧基苯甲酸乙酯 | CAS号3943-89-3 3,4-二羟基苯甲酸乙酯 | CAS号74-96-4 溴乙烷 | CAS号63477-41-8 trans-2-ethoxy-... | CAS号2029-95-0 1,2-diethoxy-4-... | CAS号2539-53-9 4-乙氧基-3-羟基苯甲醛 | CAS号20197-72-2 2-氨基-4,5-二乙氧基苯甲酸 | CAS号98-88-4 苯甲酰氯 | CAS号27472-20-4 4-氯甲基-1,2-二乙氧基苯 | CAS号83459-29-4 3,4-二乙氧基苄醇 | CAS号2050-46-6 邻苯二乙醚 | CAS号27472-21-5 2-(3,4-二乙氧基苯基)乙腈 | CAS号75332-44-4 3,4-二乙氧基苯甲酸乙酯 | CAS号103796-34-5 4,5-二乙氧基-2-硝基苯甲酸 | CAS号179246-15-2 6,7-二乙氧基喹唑啉-4(3H)-酮 | CAS号162363-46-4 4-氯-6,7-二乙氧基喹唑啉

Methyl 3,4-Diethoxybenzoate置于水,Sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应 1.5H,以99%的收率获得产物3,4-二乙氧基苯甲酸
参考文献: Heteroaromatic Derivatives And Pharmaceutical Applications Thereof[fr] Dérivés Hétéroaromatiques Et Leurs Applications Pharmaceutiques
标题: Heteroaromatic Derivatives And Pharmaceutical Applications Thereof[fr] Dérivés Hétéroaromatiques Et Leurs Applications Pharmaceutiques
摘要:本文提供了新颖的杂环芳烃衍生物,或其立体异构体,几何异构体,互变异构体,N-氧化物,水合物,溶剂合物,前药,药用盐或其前药,以及含有这些化合物的药物组合物.本文还提供了这些化合物或药物组合物在制造用于治疗呼吸道疾病,特别是慢性阻塞性肺病(copd)的药物中的用途.

专利信息

专利号:US-8507538-B2
优先权日:2009-11-13
标 题:Selective heterocyclic sphingosine 1 phosphate receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD
权利人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD; RECEPTOS INC
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-9481659-B2
优先权日:2011-05-13
标 题 :Selective heterocyclic sphingosine 1 phosphate receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD
权利人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD; CELGENE INT II SÀRL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.