CAS: 56456-47-4; 2,4-Difluorobenzyl Alcohol

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CAS号1550-35-2 2,4-二氟苯甲醛 | CAS号106614-28-2 2,4-二氟苯甲酸甲酯 | CAS号23915-07-3 2,4-二氟溴苄 | CAS号1550-35-2 2,4-二氟苯甲醛

2,4-二氟苯甲醛置于sodium Tetrahydroborate体系中,用 甲醇 作为反应溶剂,化学反应 4.0H,反应生成 2,4-二氟苄醇
参考文献:新型基于吲哚和三唑的杂合分子通过激活wnt3A /β-Catenin途径表现出有效的抗脂肪形成和抗血脂异常活性
标题:新型基于吲哚和三唑的杂合分子通过激活wnt3A /β-Catenin途径表现出有效的抗脂肪形成和抗血脂异常活性
摘要:肥胖和血脂异常是代谢综合征的两个方面,需要进一步关注.最近的研究表明三唑和吲哚衍生物具有显着的抗肥胖/抗血脂异常活性.为了利用上述潜力,使用点击化学方法制备了一系列新颖的三唑棒状吲哚衍生物,并评估了其抗脂肪形成的活性.基于结构-活性关系,确定了增强抗脂肪形成活性的基本官能团.铅化合物13米相比于1.67的ic-50值其父化合物显示出有效的抗脂肪反应生成活性 μm.在不同的细胞系(例如c3H10T1 / 2和hmsc)中进行了抗脂肪形成活性的进一步评估,结果均为阳性.化合物13M的抗脂肪形成作用在脂肪形成的早期最为显着,这是由有丝分裂克隆扩增过程中的g1到s期细胞周期停滞所驱动的.机理研究表明,化合物13M通过激活wnt3A /β-Catenin途径(已知的关键成脂基因pparγ和c /ebpα的抑制剂)发挥抗脂肪形成作用.值得注意的是,在血脂异常的叙利亚金仓鼠模型中,化合物13M还降低了血清甘
DOI:10.1016/j.Ejmech.2017.10.034

专利信息

专利号:US-4273947-A
优先权日:1979-01-31
标 题:Hydrogenation of fluorine-containing carboxylic acids
发明人：NOVOTNY MIROSLAV
权利人:ALLIED CHEM
摘要:A process is described for the heterogeneous hydrogenation of fluorine-containing alkyl, cycloalkyl, and benzene carboxylic acids to the corresponding primary alcohols. The hydrogenation can be carried out in the liquid or vapor phase in the presence of a solid rhodium or iridium catalyst, employed as the metal, metallic oxide, or mixture thereof. In the liquid phase, the hydrogenation can be carried out batchwise under mild conditions of temperature and pressure, preferably at about 50°-150° C. and about 5-15 atmospheres, in an atmosphere containing hydrogen gas. A preferred embodiment is the hydrogenation of trifluoroacetic acid in the liquid phase to 2,2,2-trifluoroethanol, said alcohol being useful as an intermediate in the synthesis of the anesthetic, isoflurane, CF 3 CHClOCHF 2 .

专利号:US-4255594-A
优先权日:1979-09-18
标题 :Hydrogenation of halogen-containing carboxylic anhydrides
发明人：NOVOTNY MIROSLAV
权利人:ALLIED CHEM
摘要:A process is described for the heterogeneous hydrogenation of haloalkyl, halocycloalkyl or haloaryl carboxylic anhydrides to the corresponding primary alcohols. In the haloalkyl or halocycloalkyl carboxylic anhydrides at least one halogen is in the alpha-position relative to the carboxylic anhydride grouping. The hydrogenation can be carried out in the liquid or vapor phase in the presence of a supported or unsupported catalyst comprising a member of the group consisting of rhodium, iridium, metal oxides thereof, or mixtures thereof. In the liquid phase, the hydrogenation can be carried out batchwise under mild conditions of temperature and pressure, preferably at about 50°-150° C. and about 5-15 atmospheres, in an atmosphere containing hydrogen gas. A preferred embodiment is the hydrogenation of trifluoroacetic anhydride in the liquid phase to 2,2,2-trifluoroethanol, said alcohol being useful as an intermediate in the synthesis of the anesthetic, isoflurane, CF 3 CHClOCHF 2 .

专利号:US-4710513-A
优先权日:1979-08-17
标 题:Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

专利号:US-4459422-A
优先权日:1979-08-17
标 题:Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

专利号:US-4375475-A
优先权日:1979-08-17
标 题 :Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

专利号:US-4567289-A
优先权日:1979-08-17
标 题 :Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihyd roxy-6-heptenoic acid of structural formula: are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.