CAS: 570391-20-7; 3-Bromo-5-Iodophenol

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CAS号915412-18-9 1-溴-3-碘-5-甲氧基苯 | CAS号591-18-4 1-溴-3-碘苯

2,6-二溴-4-硝基苯胺置于氢氧化钾,正丁基锂,硫酸,四丁基溴化铵,氢溴酸,正丁基氯化镁,溶剂黄146,1,1,3,3-四甲基脲,Sodium Nitrite体系中,用 乙醇,正己烷,水,甲苯 作为反应溶剂,化学反应 77.58H,反应生成 3-溴-5-碘苯酚
参考文献:Anti-Cancer Agents And Uses Thereof
标题:Anti-Cancer Agents And Uses Thereof
摘要:本发明涉及新化合物及其盐,它们的合成以及它们作为抗癌剂的用途.这些化合物包括式i的化合物: 和其溶剂化物,水合物和药用可接受盐,其中a 1 为n或cr 1 ;a 3 为n或cr 3 ;a 5 为n或cr 5 ;r 1,R 3-R 6 和l在规范中定义;n为0或1;x为在环部分具有6-10个碳的可选择取代芳基,在环部分具有1-3个氮原子的可选择取代的6元杂芳基,在环部分具有0-4个氮原子且可选择在环部分有1个硫原子或1个氧原子的可选择取代的5元杂芳基,或者在其中6元环与5元环或6元环融合的可选择取代的杂芳基,其中在每种情况下1,2,3或4个环原子是从氮,氧和硫中独立选择的杂原子.它们对广泛范围的癌症,特别是白血病,前列腺癌,非小细胞肺癌和结肠癌有效.它们还可用于治疗增殖性视网膜病变,如糖尿病神经病变和黄斑变性.

专利信息

专利号:US-6828466-B2
优先权日:2002-07-19
标题:Process for the synthesis of phenols from arenes
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
权利人:UNIV MICHIGAN STATE
摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

专利号:US-2004030197-A1
优先权日:2002-07-19
标 题 :Process for the synthesis of phenols from arenes